Elicitation of pharmacologically active phenolic compounds from Rauvolfia serpentina Benth. Ex. Kurtz.

Nair, Vadakkemuriyil Divya; Panneerselvam, R.; Gopi, R.; Shao, Hongbo

doi:10.1016/j.indcrop.2013.01.008

Cited by 21 publications

(11 citation statements)

References 57 publications

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“…in Hypericum perforatum L. [47], phenolic acids and rutin in Rauvolfia serpentina [48], capsaicin in Capsicum frutescens [49] and taxol in Taxus chinensis cell suspension cultures [50]. Parallel to our results, RA biosynthesis was also increased by SA in several plant species, such as Coleus forskohlii hairy root cultures [23], Solenostemon scutellarioides [22] and S. miltiorrhiza cell cultures [21].…”

Section: Accumulations Of Phenolic Acids and Total Flavonoids After Tsupporting

confidence: 88%

Enhanced production of phenolic acids in Salvia miltiorrhiza hairy root cultures by combing the RNAi-mediated silencing of chalcone synthase gene with salicylic acid treatment

Zhang

Liang

et al. 2015

Biochemical Engineering Journal

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Section: Accumulations Of Phenolic Acids and Total Flavonoids After Tsupporting

confidence: 88%

Enhanced production of phenolic acids in Salvia miltiorrhiza hairy root cultures by combing the RNAi-mediated silencing of chalcone synthase gene with salicylic acid treatment

Zhang

Liang

et al. 2015

Biochemical Engineering Journal

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“…Phenolic compounds are a large group of secondary metabolites extensively distributed in plants, and they can be divided into two main subgroups: flavonoids and phenolic acids. Previous studies have suggested that polyphenols may play a vital role in preventing obesity, coronary heart disease, colon cancer, and gastrointestinal disorders, and they can also reduce the risk of diabetes [5]. Harvesting from the root cannot meet the growing demand for AQs and phenolic compounds for medical and commercial uses, and it also raises serious ecological concerns [1].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Production of Anthraquinones and Phenolic Compounds and Biological Activities in the Cell Suspension Cultures of Polygonum multiflorum

Thiruvengadam

Rekha

Rajakumar

et al. 2016

IJMS

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Anthraquinones (AQs) and phenolic compounds are important phytochemicals that are biosynthesized in cell suspension cultures of Polygonum multiflorum. We wanted to optimize the effects of plant growth regulators (PGRs), media, sucrose, l-glutamine, jasmonic acid (JA), and salicylic acid (SA) for the production of phytochemicals and biomass accumulation in a cell suspension culture of P. multiflorum. The medium containing Murashige and Skoog (MS) salts and 4% sucrose supplemented with 1 mg/L 2,4-dichlorophenoxyacetic acid, 0.5 mg/L thidiazuron, and 100 µM l-glutamine at 28 days of cell suspension culture was suitable for biomass accumulation and AQ production. Maximum biomass accumulation (12.5 and 12.35 g fresh mass (FM); 3 and 2.93 g dry mass (DM)) and AQ production (emodin 295.20 and 282 mg/g DM; physcion 421.55 and 410.25 mg/g DM) were observed using 100 µM JA and SA, respectively. JA- and SA-elicited cell cultures showed several-fold higher biomass accumulation and AQ production than the control cell cultures. Furthermore, the cell suspension cultures effectively produced 23 phenolic compounds, such as flavonols and hydroxycinnamic and hydroxybenzoic acid derivatives. PGR-, JA-, and SA-elicited cell cultures produced a higher amount of AQs and phenolic compounds. Because of these metabolic changes, the antioxidant, antimicrobial, and anticancer activities were high in the PGR-, JA-, and SA-elicited cell cultures. The results showed that the elicitors (JA and SA) induced the enhancement of biomass accumulation and phytochemical (AQs and phenolic compounds) production as well as biological activities in the cell suspension cultures of P. multiflorum. This optimized protocol can be developed for large-scale biomass accumulation and production of phytochemicals (AQs and phenolic compounds) from cell suspension cultures, and the phytochemicals can be used for various biological activities.

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“…These include, e.g. caffeic acid and salvianolic acid from Salia miltiorrhiza (Dong et al 2010), phenolic acids (cichoric acid and chlorogenic acid) from Rauvolfia serpentine (Nair et al 2013), p-coumaroylmalic acid from Thunbergia alata (Housti et al 2002). Due to their stress-related accumulation phenols are considered as stress metabolites.…”

Section: Discussionmentioning

confidence: 99%

Salicylic acid regulates secondary metabolites content in leaves of Matricaria chamomilla

2013

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The influence of increasing doses of salicylic acid (SA) on selected physiological parameters and the content of coumarin-related compounds of diploid and tetraploid cultivars of Matricaria chamomilla plants were studied. Forty-eight hours after treatment SA showed growth-promoting effect with decrease in tissue water content, chlorophylls and soluble proteins. High doses of SA led to an increase of reactive oxygen species (hydrogen peroxide and superoxide radical) resulted in membrane damage (measured by accumulation of malondialdehyde). Changes in secondary metabolites accumulation in leaves were also observed. The pattern of quantitative changes of studied compounds was similar in tetraploid and diploid plants. The content of herniarin and its precursor (Z )-and (E )-2-β-D-glucopyranosyloxy-4-methoxycinnamic acid increased simultaneously. A considerable increase of umbelliferone and decrease in chlorogenic acid was registered. The rise of ene-yne-dicycloether in treated plant was also detected.

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Elicitation of pharmacologically active phenolic compounds from Rauvolfia serpentina Benth. Ex. Kurtz.

Cited by 21 publications

References 57 publications

Enhanced production of phenolic acids in Salvia miltiorrhiza hairy root cultures by combing the RNAi-mediated silencing of chalcone synthase gene with salicylic acid treatment

Enhanced production of phenolic acids in Salvia miltiorrhiza hairy root cultures by combing the RNAi-mediated silencing of chalcone synthase gene with salicylic acid treatment

Enhanced Production of Anthraquinones and Phenolic Compounds and Biological Activities in the Cell Suspension Cultures of Polygonum multiflorum

Salicylic acid regulates secondary metabolites content in leaves of Matricaria chamomilla

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