Eliciting patient preferences for hormonal therapy options in the treatment of metastatic prostate cancer

Abstract

Treatment choices for metastatic prostate cancer are complex and can involve men balancing survival versus quality of life. The present study aims to elicit patient preferences with respect to the attributes of treatments for metastatic prostate cancer through a discrete choice experiment (DCE) questionnaire. Men with recently diagnosed localized prostate cancer were asked to envisage that they had metastatic disease when completing a survey. As expected, men with prostate cancer placed considerable importance on gains in survival; however, avoiding side effects of treatment was also clearly important. Survival gains should be considered alongside side effects when discussing treatment options in metastatic disease.

Evaluation of Patient Preference and Willingness to Pay for Attributes of Maintenance Medication for Chronic Obstructive Pulmonary Disease (COPD)

“…In phase II, a quantitative study using DCE methodology was designed based on the qualitative findings obtained in phase I. DCE is a type of conjoint analysis [20–24], and can be used to estimate willingness to pay (WTP) for healthcare interventions [25, 26]. The method allows respondents to choose their preferred option between hypothetical scenarios designed to reflect the different attributes that real world decisions would contain, and allow them to make ‘trade-offs’ between these attributes to reveal their preferences.…”

Attitudes of prostate cancer patients towards the diagnosis and treatment of their disease: findings from a multinational survey

“…The preferences of patients when making informed treatment decisions about prostate cancer have also been examined. When men with recently diagnosed non-metastatic prostate cancer were asked to imagine that they had metastatic disease, most participants felt that improving survival time was the most important issue, but also placed considerable emphasis on the potential side effects and convenience of treatment 4 .…”

Patients’ Preferences for the Treatment of Metastatic Castrate-resistant Prostate Cancer: A Discrete Choice Experiment

“…The DCE method has been used to estimate patients' preferences for different treatment characteristics (attributes) in men with prostate cancer. [21][22][23][24][25][26][27] Using this approach, the key attributes of treatments are identified, which in turn are described by a series of discrete levels. For example, the attribute of extreme tiredness may have the associated levels of 30%, 40%, or 50% of patients feeling extreme tiredness.…”