Contemporary developmental models emphasize the synthesis of prevention and promotion perspectives in order to reduce young people's likelihood of engaging in violent, aggressive, and other problematic behaviors and maximize their potential for positive development. In light of their holistic and integrated approach, models that are derived from the relational developmental systems (RDS) metamodel (e.g., the positive youth development perspective) represent ideal frames through which to enrich understanding of how to align individual and ecological developmental assets in order to promote thriving among diverse youth. I discuss how the key ideas reflected in the RDS metamodel may inform effective approaches for preventing youth violence and problematic functioning (more broadly) and promoting thriving (namely, in the form of resilience). I explore these ideas within the context of empirical work suggesting the roles of individual and ecological developmental assets in prevention and promotion, and discuss important considerations for future research and practice.