2018
DOI: 10.1002/jia2.25059
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Eliminating hepatitis C virus as a public health threat among HIV‐positive men who have sex with men: a multi‐modelling approach to understand differences in sexual risk behaviour

Abstract: IntroductionOutbreaks of hepatitis C virus (HCV) infections among HIV‐positive men who have sex with men (MSM) have been observed globally. Using a multi‐modelling approach we estimate the time and number of direct‐acting antiviral treatment courses required to achieve an 80% reduction in HCV prevalence among HIV‐positive MSM in the state of Victoria, Australia.MethodsThree models of HCV transmission, testing and treatment among MSM were compared: a dynamic compartmental model; an agent‐based model (ABM) param… Show more

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Cited by 24 publications
(13 citation statements)
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“…Rapidly linking these patients to treatment is crucial in breaking the network of transmission. [24] Our SVR rate of 96%, in keeping with existing trial as well as realworld experience data, is encouraging. [25] When we excluded our failed sofosbuvir/ribavirin patients from this assessment, SVR was 98%.…”
Section: Researchsupporting
confidence: 72%
“…Rapidly linking these patients to treatment is crucial in breaking the network of transmission. [24] Our SVR rate of 96%, in keeping with existing trial as well as realworld experience data, is encouraging. [25] When we excluded our failed sofosbuvir/ribavirin patients from this assessment, SVR was 98%.…”
Section: Researchsupporting
confidence: 72%
“…As regards the reasons associated with treating <50% of patients, physician and nurse understaffing were associated with treating <50% of patients, respectively, in 15 and 16 of the 18 steps of the services, while the other reasons were significantly associated with treating <50% of patients in less steps of services (5)(6)(7)(8)(9)(10)(11)(12)). The answer 'We follow the recommendations' was negatively associated with treating <50% of patients in all the services and the steps in which the answer option was included.…”
Section: Descriptive Statisticsmentioning
confidence: 98%
“…In Australia, publicly subsidized DAA treatment was made available from 1 March 2016 to anyone living with HCV, regardless of disease progression and ongoing risk behaviours , making possible the elimination of HCV as a public health threat by 2030 . A concentrated epidemic of HCV infection among GBM living with diagnosed HIV means that scale‐up of DAA treatment in this population could lead to substantial reductions in HCV transmission , facilitating elimination . However, evidence of high rates of HCV reinfection among “sexually adventurous” GBM with recurring exposure in the interferon treatment era suggests that applying a treatment‐as‐prevention approach on its own may not be sufficient to achieve elimination of HCV/HIV co‐infection among GBM.…”
Section: Introductionmentioning
confidence: 99%