T he dynamic nature of the OR poses unique safety challenges for the personnel working in this area. Perioperative nurses can sustain injuries during and after procedures as well as when moving patients. 1 Results of a 2016 staff survey at a Level 1 trauma center in Boston, Massachusetts, showed that the leading behavioral causes for injury were rushing, fatigue, and lifting; and the top three environmental conditions that led to injury (in descending order) were wet floors, electrical cords on floors, and pushing large equipment. 1 Data encompassing 2021 and 2022 from the US Bureau of Labor Statistics indicated that the top three events that contributed to injuries among health care personnel were• exposure to harmful environments or substances;• overexertion and the resulting bodily reactions; and• slips, trips, and falls. 2The data showed that approximately 224,000 health care employees were unable to work for at least one day, and approximately 61,000 employees required at least one day of job restriction or transfer. 2The ergonomic demands in perioperative areas associated with specialty equipment and limited space reveal a critical need to safeguard personnel well-being through hazard mitigation. This article reviews safety concerns for personnel working in the OR and focuses on ways to avoid them.