Elimination diet and intestinal permeability in atopic eczema: a preliminary study

Caffarelli, Carlo; Cavagni, Giovanni; Menzies, Ian S.; Bertolini, Patrizia; Atherton, D. J.

doi:10.1111/j.1365-2222.1993.tb02480.x

Cited by 42 publications

(32 citation statements)

References 18 publications

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“…Phenomena such as the increase of intestinal permeability and circulating immune complexes, can be associated with clinical symptoms in different organs and tissues, and this data are confirmed by the fact that increased intestinal permeability is reduced by effective elimination diet that excludes offending foods [15]. The higher incidence of food allergy in infants seems to be linked to the fact that infants are particularly prone to adverse reaction to cow’s milk proteins.…”

Section: Introductionmentioning

confidence: 98%

The immunopathogenesis of cow’s milk protein allergy (CMPA)

et al. 2012

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The most frequent symptoms among the manifestations of cow milk protein allergy (CMPA) are gastrointestinal. CMPA pathogenesis involves immunological mechanisms with participation of immunocompetent cells and production of immunoglobulin E (IgE). Nevertheless, recent studies have been focused on the description of other forms of CMPA, not-mediated by IgE reactions, mostly involving the T lymphocite immune system. Thus, in this field it is important to note how different kind of cells are involved in the immunopathogenesis of CMPA, such as antigen-specific T cells, T regulatory cells, cytokines secreted by the different T lymphocite subsets, B lymphocytes, antingen-presenting cells, mast cells, that together orchestrate the complex mechanism leading to the phenotipic expression of CMPA.The progress in the diagnosis of immunologic disorders allowed the recent literature to develop new models for immuno-mediate disorders, involving new cells (such as Treg cells) and thus allowing the acquisition of a new vision of the pathogenesis of atopic diseases.The aim of this review is to describe the immunopathogenetic aspects of CMPA in view of these new discoveries in the immunologic field, considering the immunologic pathway at the basis of both IgE- and not-IgE mediated CMPA.

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Section: Introductionmentioning

confidence: 98%

The immunopathogenesis of cow’s milk protein allergy (CMPA)

et al. 2012

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“…52 53 Furthermore, increased intestinal permeability has been described in patients with food allergies, eczema and asthma compared with healthy subjects. [54][55][56][57] Finally, it has also been suggested that infants susceptible to the development of allergies are also susceptible to aberrant colonisation of the gut. However, this explanation seems less likely since we have controlled for familial history of atopy.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study

Penders

Thijs

Brandt

et al. 2007

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Background and aims: Perturbations in intestinal microbiota composition due to lifestyle changes may be involved in the development of atopic diseases. We examined gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation. Methods: The faeces of 957 infants aged 1 month and participating in the KOALA Birth Cohort Study were analysed using quantitative real-time PCR. Information on atopic symptoms (eczema, wheeze) and potential confounders was acquired through repeated questionnaires. Total and specific IgE were measured in venous blood samples collected during home visits when the infant was 2 years old. During these home visits a clinical diagnosis of atopic dermatitis was made according to the UK-Working Party criteria. Results: The presence of Escherichia coli was associated with a higher risk of developing eczema (OR adj = 1.87; 95% CI 1.15 to 3.04), this risk being increased with increasing numbers of E coli (p for

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“…Many studies that have examined relatively small numbers of patients found no evidence of altered permeability [84][85][86] while several others have found abnormalities in a subgroup of patients. [87][88][89] In at least some of these patients relief of symptoms has accompanied probiotic treatment 90 and in one study probiotics not only reduced the skin disease but also decreased elevated small intestinal permeability. 91 It is unclear from this study whether the increased permeability was a cause of the atopic dermatitis or an associated area of inflammation.…”

Section: Other Diseasesmentioning

confidence: 99%