2002
DOI: 10.1097/00003246-200210000-00006
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Elimination kinetics of myoglobin and creatine kinase in rhabdomyolysis: Implications for follow-up

Abstract: Serum myoglobin has faster elimination kinetics than creatine kinase in patients treated with forced alkaline diuresis for rhabdomyolysis. Considering the etiologic role of myoglobin, our data suggest that serum myoglobin level, rather than that of creatine kinase, should be used to guide therapy in patients with rhabdomyolysis.

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Cited by 95 publications
(75 citation statements)
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“…No paciente pediátrico do relato, constituiu o primeiro sintoma, observado ainda no intra-operatório, permitindo um tratamento precoce. O diagnóstico clássico da rabdomiólise depende do reconhecimento dos fatores de risco, como a presença de dor muscular, de urina avermelhada ou marrom e, principalmente, pela presença dos indicadores de lesão muscular, CK e mioglobina 1, 24 . O diagnóstico definitivo é laboratorial, podendo ser indicada a tomografia computadorizada ou a ressonância magnética, para localizar os músculos acometidos, quando houver indicação de desbridamento cirúrgico 22 ou apenas para avaliar a extensão da lesão.…”
Section: Discussionunclassified
“…No paciente pediátrico do relato, constituiu o primeiro sintoma, observado ainda no intra-operatório, permitindo um tratamento precoce. O diagnóstico clássico da rabdomiólise depende do reconhecimento dos fatores de risco, como a presença de dor muscular, de urina avermelhada ou marrom e, principalmente, pela presença dos indicadores de lesão muscular, CK e mioglobina 1, 24 . O diagnóstico definitivo é laboratorial, podendo ser indicada a tomografia computadorizada ou a ressonância magnética, para localizar os músculos acometidos, quando houver indicação de desbridamento cirúrgico 22 ou apenas para avaliar a extensão da lesão.…”
Section: Discussionunclassified
“…A more prolonged period of immobilization on the operating room table could have contributed to the accumulation of additional serum CK. 71 Serum CK clearance also depends on renal function, 72 which was not accounted for in the study by Bergin and colleagues. 68 Another study 73 examined the extent of gluteus medius/ minimus, TFL, rectus femoris and short external rotator muscle damage in THAs performed on 12 cadaveric hips (6 direct anterior and 6 direct posterior approaches).…”
Section: Anterior Versus Posterior Approachmentioning
confidence: 99%
“…Serum creatine kinase (CK), also increased in rhabdomyolysis, was measured in 38 studies (11, 13-28, 30 -34, 36 -38, 40 -45, 47, 52, 56, 57, 61-63 ), and of these, only 4 had extractable data comparing uMb with CK (45,47,51,59 ). Serum myoglobin was also measured in addition to urine myoglobin in 11 studies (19,20,23,31,40,41,43,44,46,59,61 ), but only 1 study had extractable data for a contingency table (59 ).…”
Section: Study Characteristicsmentioning
confidence: 99%