Elimination of iodine deficiency disorders from the Americas: a public health triumph

Pretell, Eduardo; Pearce, Elizabeth N.; Moreno, Sergio; Dary, Omar; Kupka, Roland; Gizak, Małgorzata; Gorstein, Jonathan; Grajeda, Rubén; Zimmermann, Michael

doi:10.1016/s2213-8587(17)30034-7

Cited by 17 publications

(16 citation statements)

References 4 publications

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“…DUOX2 encodes a trans-membrane component of an NADPH oxidase, which produces hydrogen peroxide (H 2 O 2 ), and is essential for the synthesis of the thyroid hormone and for the production of microbicidal hypothiocyanite anion (OSCN-) during mucosal innate immunity response against bacterial and viral infections in the airways and intestines 45,46 . Mutations in DUOX2 produce inherited hypothyroidism 47 Before the introduction of the public health program of supplementing manufactured salt with iodine, one of the environmental stresses of the Andes for human populations was iodine deficiency, which impairs thyroid hormone synthesis, increasing the risk of developing hypothyroidism, goiter, obstetric complications and cognitive impairment 49,50 .…”

Section: Yunga and Amazon And Its Relationship With Archaeological Chmentioning

confidence: 99%

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

Borda

Alvim

Mendes

et al. 2020

Preprint

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Western South America was one of the worldwide cradles of civilization. The well known Inca Empire was the tip of the iceberg of a cultural and biological evolutionary process that started 14-11 thousand years ago. Genetic data from 18 Peruvian populations reveal that: (1) The between-population homogenization of the central-southern Andes and its differentiation with respect to Amazonian populations of similar latitudes do not extend northward. Instead, longitudinal gene flow between the northern coast of Peru, Andes and Amazonia accompanied cultural and socioeconomic interactions revealed by archeological studies. This pattern recapitulates the environmental and cultural differentiation between the fertile north, where altitudes are lower; and the arid south, where the Andes are higher, acting as a genetic barrier between the sharply different environments of the Andes and Amazonia (2). The genetic homogenization between the populations of the arid Andes is not only due to migration during the Inca Empire or the subsequent colonial period. It started at least during the earlier expansion of the pre-Inca Wari Empire (600-1000 YBP) (3) This demographic history allowed for cases of positive natural selection in the high and arid Andes vs. the low Amazon tropical forest: in the Andes, HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, related with cardiovascular function) and DUOX2 (dual oxidase 2, related to thyroid function and innate immunity) genes; in the Amazon, the gene encoding for the CD45 protein, essential for antigen recognition by T/B lymphocytes in viral-host interaction, consistent with the host-virus arms race hypothesis.

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Section: Yunga and Amazon And Its Relationship With Archaeological Chmentioning

confidence: 99%

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

Borda

Alvim

Mendes

et al. 2020

Preprint

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“…Iodized salt is fortified at around 45 mg of iodide/kg in the United States (2). Currently, approximately 70% of households worldwide and almost 90% of households in North and South America use iodized salt, with other common sources such as seaweed, seafood, and iodine-containing supplement (5), and the concerted global approach to eliminate IDDs has been successful at substantially decreasing the number of countries with iodine deficiency (7,8).…”

Section: Introductionmentioning

confidence: 99%

Urinary Iodine Concentration and Mortality Among U.S. Adults

Inoue

Leung

Sugiyama

et al. 2018

Thyroid

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“…практически во всех странах Америки были приняты законы о йодировании соли (за исключением Гаити, Гайаны и Белиза). Это привело к тому, что на форуме по микроэлементам на глобальной конференции в Канкуне, Мексика, 24 -28 октября 2016 г. было объявлено о победе над йододефицитными заболеваниями в Северной и Южной Америке [16]. По данным Глобальной Сети по йоду, в 2017 году среди всех американских стран только в Гаити отмечается умеренный дефицит йода.…”

Section: актуальностьunclassified

“…По данным Глобальной Сети по йоду, в 2017 году среди всех американских стран только в Гаити отмечается умеренный дефицит йода. В остальных странах данного региона мКЙМ колеблется от 123 мг/л (Аргентина) до 415 мг/л (Колумбия) [6,16]. Также стоит отметить, что среди всех регионов ВОЗ на территории Америки отмечается самый большой процент домохозяйств, использующих в быту йодированную соль [16].…”

Section: актуальностьunclassified

“…В остальных странах данного региона мКЙМ колеблется от 123 мг/л (Аргентина) до 415 мг/л (Колумбия) [6,16]. Также стоит отметить, что среди всех регионов ВОЗ на территории Америки отмечается самый большой процент домохозяйств, использующих в быту йодированную соль [16]. В исследовании 2014 г. были выявлены статистически значимые различия в йодном статусе жителей г. Москвы и Московской области.…”

Section: актуальностьunclassified

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Iodine status of the population in Russia and the world: what do we have for 2019?

Алфёрова¹,

Мустафина²,

Рымар³

2019

Clin Exp Thyroid

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The article presents the most relevant data of the world literature on the problem of iodine status. The problem of iodine deficiency still remains unresolved on the territory of the former Soviet Union (the median urinary iodine was 29.1 μg/l in Abkhazia, and almost 30% of the examined had the level of ioduria below standard values in Kazakhstan), although some countries have been successful in dealing with iodine deficiency (the median urinary iodine is 191 μg/l in Belarus, 169 μg/l in Ukraine). On the rest of the Eurasian continent, the picture is also different: among the total mass of countries with normal median urinary iodine, there are territories with both iodine deficiency (the median of ioduria ranges from 80 to 138 μg/l in the UK, the median of ioduria is 63 μg/l in France) and its excessive consumption (the median of ioduria is 330.0 μg/l in China). On the territory of America, in 2016, the elimination of iodine deficiency was announced (the median of ioduria ranged from 123 μg/l (Argentina) to 415 μg/l (Colombia)), and Haiti was the only country with a fixed iodine deficiency – 84 μg/l. Research data from different years in the following regions of the Russian Federation are presented: Moscow (the median of ioduria 67.0 μg/l), St. Petersburg (66.0–86.0 μg/l), Tyumen region (106.9 μg/l), Novosibirsk region (93.0 μg/l), Republic of Bashkortostan (70.3 μg/l), Republic of Dagestan (65.8 μg/l), Kemerovo region (90.0 μg/l), Saratov region (59.0–106.0 μg/l), Tomsk region (94 μg/l), Far Eastern region (58.0–74 μg/l), Chelyabinsk region (92.0–164.5 μg/l), Chuvash Republic (72.0 μg/l), Perm region (100.0 μg/l). Almost throughout the Russian Federation, iodine deficiency of mild severity was noted.

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Elimination of iodine deficiency disorders from the Americas: a public health triumph

Cited by 17 publications

References 4 publications

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture

Urinary Iodine Concentration and Mortality Among U.S. Adults

Iodine status of the population in Russia and the world: what do we have for 2019?

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