1986
DOI: 10.1002/ijc.2910370215
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Elimination of murine erythroleukemic stem cells with a novel anti‐erythroid antibody conjugated to ricin a‐chain: A model for studies of bone‐marrow transplantation therapy

Abstract: We have produced a rat monoclonal antibody (MAb) MAE15 (IgG), specific for murine erythroid cells, using a murine erythroid cell line as immunogen. This MAb specifically binds to the surface of normal and neoplastic murine erythroid cells. Murine mature erythrocytes and non-erythroid cells as well as rat and human erythroid and non-erythroid cells are not recognized by MAb MAE15. Immunoblotting analysis and mixed precipitation in agar gel showed MAb MAE15 to be specific for murine epitope of 69 kDa antigen of … Show more

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Cited by 12 publications
(3 citation statements)
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“…The cytotoxic effect of ricin was determined by measuring the inhibition of ['%Jleucine incorporation into EB-3 cells caused by the toxin [12].…”
Section: Treatment Of Cells With Neuram~nidusementioning
confidence: 99%
“…The cytotoxic effect of ricin was determined by measuring the inhibition of ['%Jleucine incorporation into EB-3 cells caused by the toxin [12].…”
Section: Treatment Of Cells With Neuram~nidusementioning
confidence: 99%
“…In previous reports [1,2,3], an inter-species 70 kD membrane glycoprotein specific for mammalian erythroid cells, in particular, erythroblasts (Ag-Eb) was described. MAB HAE9 directed against a human epitope of Ag-Eb is reactive with 36% of late committed erythroid progenitors (CFU-E), almost 100% of proerythroblasts, erythroblasts, and normoblasts.…”
Section: Introductionmentioning
confidence: 99%
“…In previous reports (Ievleva et al, 1976;Tonevitsky et al, 1986;Mechetner et al, 1987) we described an inter-species 70 kDa antigen specific for mammalian nucleated erythroid cells, an antigen of erythroblasts (Ag-Eb). MAb HAE9 directed to a human epitope of Ag-Eb reacts positively with 36% of CFU-E and almost 100% of proerythroblasts, erythroblasts, normoblasts and reticulocytes.…”
mentioning
confidence: 95%