Elimination of Recurrent Hyperplastic Polyps by Eradication of Helicobacter pylori

Mocek, Frank W.; Ward, Will W.; Wolfson, Stewart E.; Rumage, William T.; Wieman, T. Jeffery

doi:10.7326/0003-4819-120-12-199406150-00006

Cited by 21 publications

(8 citation statements)

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“…These results strongly suggest that eradication of H. pylori leads to the regression and disappearance of hyperplastic gastric polyps. This relationship is supported by three case reports, by Veeremann Wauters et al [13], Mocek et al [14]and Kume et al [15], indicating that the clearance and eradication of H. pylori led to the disappearance of the hyperplastic polyps.…”

Section: Discussionsupporting

confidence: 73%

Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after Eradication of <i>Helicobacter pylori</i>: Comparison between Responder and Non-Responder Cases

Ohkusa

Miwa²,

Hojo³

et al. 2003

Digestion

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Background: Evidence indicates that eradication of Helicobacter pylori leads to the disappearance of hyperplastic polyps in the stomach. However, there are some exceptions. We have compared endoscopic and serologic findings of responder and non-responder cases with hyperplastic polyps to try to identify the cause(s), other than H. pylori infection, of the formation or growth of gastric hyperplastic polyps. Methods: We retrospectively studied 33 patients whose hyperplastic polyps disappeared after eradication of H. pylori and 10 patients whose hyperplastic polyps did not disappear after eradication. The patients were examined both endoscopically and serologically before, 1–3 months after and 12–15 months after the eradication. Results: The responder and non-responder groups were similar with respect to age, sex, coexisting diseases, and histologic findings. The number and maximum size of polyps tended to be larger before treatment in the non-responder group than in the responder group. The serum gastrin level was higher in the non-responder group than in the responder group before, 1–3 months after and 12–15 months after the eradication (p = 0.0096, p > 0.2, p = 0.0014). On histologic examination, similar reductions in the degree of inflammatory cell infiltration in the gastric mucosa of the antrum and body were seen in both the responder and non-responder groups. In the non-responders, the size and numbers of the polyps regressed in 5 of the 10 patients. The score of glandular atrophy in the antrum and the serum gastrin levels in the non-regressed cases was higher than those in the regressed cases at 1–3 and 12–15 months after eradication. Conclusion: Persistent high gastrin levels were found in the non-responder cases with gastric hyperplastic polyps.

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Section: Discussionsupporting

confidence: 73%

Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after Eradication of <i>Helicobacter pylori</i>: Comparison between Responder and Non-Responder Cases

Ohkusa

Miwa²,

Hojo³

et al. 2003

Digestion

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“…Ljubicic et al [14] also reported regression of hyperplastic polyps following Hp eradication treatment in 16 of 21 patients with Hp gastritis. Following Hp eradication, regression of multiple polyps measuring up to 2.6 cm in diameter was noted in a case report [18].…”

Section: Discussionmentioning

confidence: 96%

Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa?

2005

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It is well known from the older literature that gastric carcinomas are more likely to develop in a stomach containing hyperplastic polyps. The reason why such a stomach should represent a precancerous condition is, however, largely unexplained. The aim of this study was to determine the disorders of the gastric mucosa in which hyperplastic polyps occur. In 244 patients with hyperplastic polyp, in whom at least two additional biopsies each from the antrum and corpus were available, gastritis was classified on the basis of the updated Sydney System. In none of the 244 patients was the gastric mucosa found to be normal. The most common disorder, at 51.3%, was autoimmune gastritis of the corpus mucosa, while chronic active Helicobacter pylori (Hp) gastritis was seen in 37.3% of the patients. Of the patients with Hp gastritis, 56.1% had corpus-dominant Hp gastritis. Other forms were relatively rare: when A-gastritis, corpus-dominant Hp gastritis and any other form of Hp gastritis were lumped together as a precancerous condition, these changes were found in 88.6% of the patients with hyperplastic polyps of the stomach. In the presence of hyperplastic polyps of the gastric mucosa, additional biopsies obtained from the antrum and corpus should always be performed to obtain a basis for deciding whether to apply Hp eradication treatment as potential carcinoma prophylaxis.

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“…Eradication of H. pylori results in the healing of some gastrointestinal diseases, such as chronic active gastritis, peptic ulcer diseases [41][42][43], gastric hyperplastic polyp [44], and gastric mucosa-associated lymphoid tissue lymphoma [45], as well as some diseases outside the gastrointestinal tract, such as idiopathic thrombocytopenic purpura [46,47], chronic idiopathic urticaria [48], and irondeficiency anemia in adolescents [49]. H. pylori eradication may also reduce the risk of developing gastric cancer in patients who have gastric ulcers [19,21] and in patients who have already received successful endoscopic mucosal resection of early gastric cancer [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori

Mizuno²,

et al. 2010

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Elimination of Recurrent Hyperplastic Polyps by Eradication of Helicobacter pylori

Cited by 21 publications

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Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after Eradication of <i>Helicobacter pylori</i>: Comparison between Responder and Non-Responder Cases

Endoscopic, Histological and Serologic Findings of Gastric Hyperplastic Polyps after Eradication of <i>Helicobacter pylori</i>: Comparison between Responder and Non-Responder Cases

Why is the hyperplastic polyp a marker for the precancerous condition of the gastric mucosa?

The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori

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