Elimination of the acetate interference in potassium-selective valinomycin-PVC-membranes for process-controlling during haemodialysis

Buchheister, B. M.; Herna, K.; Schindler, M. M.; Schindler, J. G.

doi:10.1007/bf00322846

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…The continuous on-line measurement of K + in whole blood during human open-heart surgery is an impressive example of the advantages of the sensor approach as compared to batch analysis. , Whereas in analyzers urine is usually diluted 369 and makes the use of PVC membranes possible, silicone rubber membranes proved to be superior for bedside monitoring of K + in undiluted urine owing to smaller anionic interferences. , Various other applications, such as use in saliva, muscles of various animals (microelectrodes and in thick-film sensor arrays 78 ), or retina (microelectrodes), , and the determination of exchangeable potassium in soils , were reported. Contrary to theoretical expectations, it was claimed that the use of added lipophilic anionic sites leads to an increased interference of acetate for a valinomycin membrane . The scarcity of the data, the fact that one of the two membranes with sites contained 112 mol % sites, a ratio at which the concentration of noncomplexed carrier is negligible, as well as the use of unbuffered solutions for solid-contact electrodes, which are notoriously sensitive to CO 2 , indicate, however, that this finding should be interpreted with care.…”

Section: K+ Sensorsmentioning

confidence: 85%

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors

1998

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and 1991, respectively. He has been working in the field of chemical sensors since 1970. Further topics of his interest are spectroscopic databases, automatic spectra interpretation, and modeling of structure−property relationships. He has published over 180 papers and 7 books. Current activities in the fields of chemical sensors and computer-aided analytical chemistry are documented on the web page http://www/ceac.ethz.ch/pretsch/. His e-mail address is pretsch@ org.chem.ethz.ch.

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Section: K+ Sensorsmentioning

confidence: 85%

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors

1998

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“…For example, the application in acetate containing dialysis solutions requires a membrane with a minimized interference to anions, in this case especially acetate (7,8). For example, the application in acetate containing dialysis solutions requires a membrane with a minimized interference to anions, in this case especially acetate (7,8).…”

Section: Resultsmentioning

confidence: 99%

Continuous Analysis in Extracorporeally Circulating Blood - A Rat Model Applying Flow-Through Ion-Selective Electrodes for the Measurement of Ca2+, K+, Na+ and pH

Heidrich¹,

Niemeier²,

Seyfarth³

1998

CCLM

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A rat model is introduced which enables investigations in anticoagulated blood with continuous measurements by a flow-through electrode system. In the present study, a potentiometric ion-selective electrode (ISE)-system was used for measuring Ca2+, K+, Na+ and pH in rats. The setup was adjusted to an extracorporeal blood-volume of 0.750 ml. This permits indirect measurements of the analytes via a dialysis membrane, with electrical separation of the ISE's and the animal. The flow-rates of blood and dialysis-solution were adjusted in such a way that water diffusing from the aqueous dialysis solution into the blood, across the dialysis membrane, does not alter the haematocrit. Polyethyleneglycol-hirudin was used for anticoagulation, since it was superior to heparin. The assembly enables continuous measurements in the living anaesthetized rat over a time period of at least 3 hours.

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“…Hence, there has been growing interest in the monitoring of blood gas, pH and electrolyte using invasive sensors. The special selectivity to K + seems to be the size fit between K + and the internal cavity of this doughnut-shaped macrocyclic molecule [117]. This sensor, still in use today, consists of an ordinary glass pH electrode covered by a CO 2premeable membrane (usually silicone) with a biocarbonate solution entrapped between them.…”

Section: Importance Of Implantable Blood-gas Ph and Electrolyte Sensorsmentioning

confidence: 99%

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

Dong²,

Cao³

et al. 2007

CMC

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Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.

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Elimination of the acetate interference in potassium-selective valinomycin-PVC-membranes for process-controlling during haemodialysis

Cited by 8 publications

References 21 publications

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors

Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 2. Ionophores for Potentiometric and Optical Sensors

Continuous Analysis in Extracorporeally Circulating Blood - A Rat Model Applying Flow-Through Ion-Selective Electrodes for the Measurement of Ca2+, K+, Na+ and pH

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

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