ELISA seroprevalence of Trypanosoma cruzi in a cohort of heart disease patients

Rodriguez, Maria-Virginia; Hernandez, W.; Garcia, Adriana N; Colato, Claudia M; Cardoza, Patricia G; Cardozo, Lizza Maria

doi:10.3855/jidc.2576

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…The results were similar to those of a previous study of 455 El Salvadorans who had been diagnosed with heart disease at the national tertiary hospital in 2010 [35]. Specifically, the study results indicated a significant association between T. cruzi seropositivity (16.7%) and residence in the Western region during childhood and youth.…”

Section: Discussionsupporting

confidence: 81%

Prevalence of Trypanosoma cruzi infection in blood donors in El Salvador between 2001 and 2011

Sasagawa

Aguilar

Ramírez

et al. 2014

J Infect Dev Ctries

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Introduction: El Salvador is regarded as a highly endemic country for Chagas disease, as evidenced by the relatively high estimated positive serology rate for Trypanosoma cruzi among blood donors. This study aimed to identify the factors contributing to this high rate by analyzing changes in T. cruzi seroprevalence. Methodology: Secondary data were collected from 31 blood banks operated by the Ministry of Health, the Red Cross, the Institute of Salvadoran Social Security, and the Military Hospital. The data were analyzed to determine the number of cases of T. cruzi seropositivity, and the average prevalence of seropositivity by province. Simple linear regression was performed to identify trends in T. cruzi seropositivity. Results: Analysis of the 885,187 blood samples collected between 2001 and 2011 revealed 21,693 cases of transfusion-related infections, with a significant reduction of T. cruzi seropositivity from 3.7% in 2001 to 1.7% in 2011, reflecting a 54% decrease over the course of a decade (R 2 = 89.6%, p > 0.001). T. cruzi seroprevalence decreased in San Salvador, Santa Ana, Sonsonate, and Cuscatlán. In contrast, seroprevalence remained high with no decrease in Ahuachapán and San Vicente, and consistently low in the remainder of the country. Conclusions: Although the national prevalence of T. cruzi among blood donors has decreased, it remains high in the provinces of Ahuachapán and San Vicente. Strengthening vector control activities and developing an approach for the systematic follow-up of prospective blood donors with positive serology for T. cruzi are required, especially in areas with high seropositivity.

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Section: Discussionsupporting

confidence: 81%

Prevalence of Trypanosoma cruzi infection in blood donors in El Salvador between 2001 and 2011

Sasagawa

Aguilar

Ramírez

et al. 2014

J Infect Dev Ctries

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“…ECG abnormalities were more prevalent in the patients with ChD than in the seronegative patients, and this has been consistently demonstrated in many studies [7][8][9][10][11][12][13] . A retrospective observational study assessed 264,324 primary-care patients including 7,590 self-reported patients with ChD.…”

Section: Prevalence Of Electrocardiographic Alterationsmentioning

confidence: 71%

Electrocardiogram in Chagas disease

Brito

Ribeiro

2018

Rev. Soc. Bras. Med. Trop.

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Since the initial descriptions of Chagas cardiomyopathy (ChCM), the electrocardiography has played a key role in patient evaluations. The diagnostic criterion of chronic ChCM is the presence of characteristic electrocardiographic (ECG) abnormalities in seropositive individuals, regardless of the presence of symptoms. However, these ECG abnormalities are rarely specific to ChCM and, particularly among the elderly, can be caused by other simultaneous cardiomyopathies. ECG abnormalities can predict the occurrence of heart failure, stroke, and even death. Nevertheless, most prognostic studies have included Chagas disease (ChD) populations and, not exclusively, ChCM. Thus, more studies are required to evaluate the efficacy of ECG in predicting reliable prognoses in established chronic ChCM. This review exclusively discusses the role of the 12-lead ECG in the clinical evaluation of chronic ChD.

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“…This interpretation is supported by an earlier study that reported a significant association between seropositivity and residence in the Western region during childhood and youth (Rodriguez et al . ).…”

Section: Discussionmentioning

confidence: 97%

Risk factors for Chagas disease among pregnant women in El Salvador

Sasagawa

Aiga

Corado

et al. 2014

Tropical Med Int Health

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Abstractobjectives To determine the seroprevalence of Chagas disease among pregnant women and estimate the risk factors for Chagas disease during pregnancies.methods Community-based serological tests on Trypanosoma cruzi and structured interviews on socio-demographic and socio-economic status were conducted with pregnant women registered at three health centres in Sonsonate province, El Salvador.results Of 797 pregnant women participating in the study, 29 (3.6%) were infected with Chagas disease. None had clinical symptoms. The results of bivariate analyses showed the significant association between seropositivity and maternal age ≥35 years, anaemia, illiteracy, having no formal school education and having knowledge on Chagas disease (P < 0.05). The results of multivariate analysis indicate that age ≥35 years and anaemia were significantly associated with being infected with Chagas disease among pregnant women (OR = 3.541 and 5.197, respectively).conclusion We recommend that the national Chagas disease control programme be better coordinated with the national maternal and child health programme to introduce blood screening for T. cruzi during antenatal visits. If financial constraint allows systematic blood screening to be only partially implemented, resources should be focused on pregnant women ≥35 years and women who have anaemia.keywords chagas disease, Trypanosoma cruzi, pregnant women, seroprevalence, El Salvador

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ELISA seroprevalence of Trypanosoma cruzi in a cohort of heart disease patients

Cited by 6 publications

References 10 publications

Prevalence of Trypanosoma cruzi infection in blood donors in El Salvador between 2001 and 2011

Prevalence of Trypanosoma cruzi infection in blood donors in El Salvador between 2001 and 2011

Electrocardiogram in Chagas disease

Risk factors for Chagas disease among pregnant women in El Salvador

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