Elite genotypes of Bacopa monnieri , with high contents of Bacoside A and Bacopaside I, from southern Western Ghats in India

Christopher, Cinthya; Johnson, Anil John; Mathew, Paravanparampil Jacob; Baby, Sabulal

doi:10.1016/j.indcrop.2017.01.018

Cited by 23 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rastogi et al reported the major bacosides in B. monnieri as bacopaside I, bacoside A3, bacopaside II, bacopasaponin C isomer and bacopasaponin C, of which the last four saponins constituted bacoside A [16]. B. monnieri accessions, with elite contents of bacoside A and bacopaside I, were recently reported from the southern Western Ghats in India [17].…”

Section: Chemistrymentioning

confidence: 99%

Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I

Sekhar

Viswanathan

Baby

2019

Self Cite

View full text Add to dashboard Cite

Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective constituent, is composed of four constituents viz., bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C (bacopaside X) and bacopasaponin C. B. monnieri extracts as well as bacosides successfully establish a healthy antioxidant environment in various tissues especially in liver and brain. Free radical scavenging, suppression of lipid peroxidation and activation of antioxidant enzymes by bacosides help to attain a physiological state of minimized oxidative stress. The molecular basis of neuroprotective activity of bacosides is attributed to the regulation of mRNA translation and surface expression of neuroreceptors such as AMPAR, NMDAR and GABAR in the various parts of the brain. Bioavailability as well as binding of neuroprotective agents (such as bacosides) to these receptors is controlled by the Blood Brain Barrier (BBB). However, nano conversion of these drug candidates easily resolves the BBB restriction and carries a promising role in future therapies. This review summarizes the neuroprotective functions of the B. monnieri extracts as well as its active compounds (bacoside A, bacopaside I) and the molecular mechanisms responsible for these pharmacological activities.

show abstract

Section: Chemistrymentioning

confidence: 99%

Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I

Sekhar

Viswanathan

Baby

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“… No. Bioactive compound Content Source (part) Reference 1 ( S )-Allyl- l -cysteine ( 38 ) 2.0–2.4 mg/100 g Allium sativum (bulb) Ryu and Kang, 2017 2 Arecoline ( 39 ) 1.5 ± 0.008% Areca catechu (raw nuts) Dutta et al, 2017 3 β-Asarone ( 40 ) 4.4% w/w Acorus calamus (rhizome) Hanson et al, 2005 4 l -Ascorbic acid ( 23 ) 34–38 mg/100 g Phyllantuhus emblica (fruit) Raghu et al, 2007 5 Bacopaside I ( 41 ) 0.29–1.36% Bacopa monnieri (whole plant) Christopher et al, 2017 6 Bacoside A ( 42 ) 1.44–5.40% Bacopa monnieri (whole plant) Christopher et al, 2017 7 Baicalin ( 43 ) Baicalein ( 44 ) 8.1–15.6% 0.2–1.2% Scutellaria baicalensis (roots) Zheljazkov et al, 2007 8 Carnosic acid ( 45 ) 18.2–35.1 mg/g Salvia rosmarinus (leaves) Hidalgo et al, 1998 9 Chebulic acid ( 46 ) 7.99 g/kg Terminalia chebula (dry fruit) Pfundstein et al, 2010 10 α-Crocin ( 47 ) >10% Crocus sativus (dry saffron's mass) Shahdadi et al, 2016 11 Curcumin ( 11 ) 3–5% Curcuma longa (rhizome) …”

Section: Other Advantageous Compoundsmentioning

confidence: 99%

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Halder

Anand

Nandy

et al. 2021

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Memory, one of the most vital aspects of the human brain, is necessary for the effective survival of an individual. ‘Memory’ can be defined in various ways but in an overall view, memory is the retention of the information that the brain grasps. Different factors are responsible for the disbalance in the brain’s hippocampus region and the acetylcholine level, which masters the memory and cognitive functions. Plants are a source of pharmacologically potent drug molecules of high efficacy. Recently herbal medicine has evolved rapidly, gaining great acceptance worldwide due to their natural origin and fewer side effects. In this review, the authors have discussed the mechanisms and pharmacological action of herbal bioactive compounds to boost memory. Moreover, this review presents an update of different herbs and natural products that could act as memory enhancers and how they can be potentially utilized in the near future for the treatment of severe brain disorders. In addition, the authors also discuss the differences in biological activity of the same herb and emphasize the requirement for a higher standardization in cultivation methods and plant processing. The demand for further studies evaluating the interactions of herbal drugs is mentioned.

show abstract

“…Due to its usage in the production of pharmaceuticals and herbal extracts, B. monnieri (Brahmi) is in very high demand in India, which promotes massive collection from their natural habitats and the extinction of the species. The greatest obstacle to the use of Brahmi in several industrial applications is the high variability in the levels of bioactive principles ( Christopher et al., 2017 ). Since ancient times, B. monnieri (Brahmi) has been used as a brain tonic or memory booster.…”

Section: Introductionmentioning

confidence: 99%

Micropropagation and elicited production of triterpenoid saponin glycosides and stigmasterol via precursor and elicitor feeding in Bacopa floribunda (R.Br.) Wettst.—A potential nootropic herb

et al. 2023

View full text Add to dashboard Cite

Bacopa floribunda (Family: Plantaginaceae) is used in folklore medicines for the management of cognitive dysfunction. It has nootropic, antiaging, anti-inflammatory, anti-cholinesterase, and antioxidant properties. We developed an efficient and reproducible protocol for in vitro propagation of B. floribunda using the nodal explants. We assessed the effects of Murashige and Skoog (MS) medium fortified with various plant growth regulatory substances (PGRs), a precursor, and elicitors and their optimal combinations on regeneration and production of total saponins, triterpenoid saponin glycosides (bacoside A3, bacopaside X, bacopaside II, and bacosaponin C), and stigmasterol content in in vitro grown biomass of B. floribunda. The growth of the shoots and roots was stimulated by MS + 2.0 mg/l BAP + 2.0 mg/l KIN and MS + 0.5 mg/l IAA + 0.5 mg/l IBA + 1.0 mg/l NAA, respectively. After 10 weeks of acclimatization, plantlets of B. floribunda had a survival rate of 95%. The highest total saponin content (35.95 ± 0.022 mg DE/g DW) was noted in the treatment of MS + 2.0 mg/l BAP + 1.5 μM SQ. Similarly, total triterpenoid saponin glycosides and stigmasterol were found maximum in biomass derived from MS + 2.0 mg/l BAP + 1.5 μM SQ and MS + 2.0 mg/l BAP, respectively. At the same treatments, bacoside A3 (1.01 ± 0.195 mg/g DW), bacopaside II (43.62 ± 0.657 mg/g DW), bacopaside X (1.23 ± 0.570 mg/g DW), bacosaponin C (0.19 ± 0.195 mg/g DW), and stigmasterol (7.69 ± 0.102 mg/g DW) were reported. The present findings will help to highlight B. floribunda as a potent memory-enhancing herb, and in future also, it could be a potential substitute to B. monnieri. The current work is the first to describe the micropropagation and the elicited production of bioactive metabolites from the in vitro grown biomass of B. floribunda. In addition, further research is needed on production of bioactives, their pharmacological effects, and the elicited production using callus, cell suspension, and hairy root cultures.

show abstract

Elite genotypes of Bacopa monnieri , with high contents of Bacoside A and Bacopaside I, from southern Western Ghats in India

Cited by 23 publications

References 20 publications

Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I

Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I

Herbal drugs and natural bioactive products as potential therapeutics: A review on pro-cognitives and brain boosters perspectives

Micropropagation and elicited production of triterpenoid saponin glycosides and stigmasterol via precursor and elicitor feeding in Bacopa floribunda (R.Br.) Wettst.—A potential nootropic herb

Contact Info

Product

Resources

About