Ellagic acid and Sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c‑Jun

Abstract

Osteosarcoma is a mesenchymally derived, high-grade bone sarcoma that is the most frequently diagnosed primary malignant bone tumor. Today, chemoprevention is regarded as a promising and realistic approach in the prevention of human cancer. Previous studies have suggested ellagic acid (EA) and Sennoside B have potential in this regard. The aim of the present study was to elucidate the anti-osteosarcoma effects of EA and Sennoside B by using Saos-2 and MG63 osteosarcoma cells. It was identified that EA or Sennoside B treatment could inhibit the growth, migration and invasion of the cells, and induce G1 cell cycle arrest by repressing the transcription of c-Jun. These results may provide a cellular basis for the application of EA or Sennoside B in the treatment of patients with osteosarcoma.

Ellagic acid induces esophageal squamous cell carcinoma cell apoptosis by modulating SHP‐1/STAT3 signaling

“…14 The anticarcinogenic effect of EA has been shown in some types of tumors, including prostate cancer, lung cancer, osteosarcoma, breast cancer, and so forth. [15][16][17][18] Consistent with previous studies, EA also showed good antitumor activity in ESCC. We found that EA inhibited ESCC cell survival by inducing cell apoptosis.…”

Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

“…Exposure of the human osteosarcoma Saos-2 and MG63 cell lines to EA resulted in a marked inhibition of cell proliferation, with G1 phase arrest, as a consequence of reduced c-Jun expression. In addition, inhibition of cell migration and invasion was observed, suggesting that EA might exert antimetastatic effects [ 124 ]. These finding are particularly relevant, since metastasis remains the most important fatal complication of osteosarcoma.…”

Structural and functional characterization of β2‐glycoprotein I domain 1 in anti‐melanoma cell migration

“…[12][13][14][15] Furthermore, many studies have reported that inhibition of cell migration decreases tumor growth in multiple cancers. [16][17][18] Therefore, it is important to elucidate the cellular basis and molecular mechanisms of β 2 -GPI function in antitumorigenesis. The present study aims to explore the specific regulatory domain and intracellular signaling of β 2 -GPI with a potential for antimelanoma progression.…”

“…It is well established that abnormal cell migration and proliferation are closely related to carcinogenesis . Furthermore, many studies have reported that inhibition of cell migration decreases tumor growth in multiple cancers . Therefore, it is important to elucidate the cellular basis and molecular mechanisms of β 2 ‐GPI function in antitumorigenesis.…”