Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity

Sepand, Mohammad Reza; Ghahremani, Mohammad Hossein; Razavi-Azarkhiavi, Kamal; Aghsami, Mehdi; Rajabi, Jalil; Keshavarz-Bahaghighat, Hedieh; Soodi, Maliheh

doi:10.1111/jphp.12589

Cited by 47 publications

(51 citation statements)

References 52 publications

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“…A study found that ellagic acid and punicalagin directly reduce ROS level produced by mitochondria . Ellagic acid was shown to exert an antioxidative effect via ameliorating mitochondrial dysfunction in concanavalin‐induced liver damage, gentamicin‐induced oxidative stress, and arsenic‐trioxide‐induced cytotoxicity in the human neuroblastoma cell line SH‐SY5Y . Cao et al .…”

Section: Mechanism Analysis Of Lipid Metabolism Regulated By Pomegranatementioning

confidence: 99%

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Hou

Zhang

et al. 2019

Molecular Nutrition Food Res

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Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic‐disorder‐associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic‐disorder‐associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate‐related nutrients or drugs.

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Section: Mechanism Analysis Of Lipid Metabolism Regulated By Pomegranatementioning

confidence: 99%

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Hou

Zhang

et al. 2019

Molecular Nutrition Food Res

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“…Therefore, apoptosis is considered as a potent therapeutic target for cancer treatment. It is believed that apoptosis can be triggered by diverse pro-apoptosis stimuli converging on mitochondria, which induces mitochondrial dysfunction such as mitochondrial depolarization, cytochrome c release, and caspase enzyme activation (8,9). In addition, mitochondria are the primary source of endogenous reactive oxygen species (ROS) and the targets of ROS in turn (9).…”

Section: Introductionmentioning

confidence: 99%

“…The staining extent was graded from 0 to 4 based on the percentage of immunoreactive tumor cells (0, 1-5, 6-25, 26-75 and 76-100%). A score ranging from 0 to 8 was calculated by multiplying the staining extent score with the staining intensity score, resulting in a low (0-4) level or a high (6)(7)(8) level for each sample (20).…”

Section: Introductionmentioning

confidence: 99%

TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation

Yue

Xiong

et al. 2017

Oncology Reports

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Abstract. Thioredoxin binding protein (thioredoxin-interacting protein, TXNIP), known as vitamin D3 increase protein 1, has been identified as a tumor suppressor in various cancers such as pancreatic, breast, lung and thyroid cancer. However, the role of TXNIP in hepatocellular carcinoma cell proliferation and apoptosis remains unknown. In this study, we first used qRT-PCR, western blotting and immunohistochemistry to compare the expression of TXNIP between hepatocellular carcinoma tissues and tumor-adjacent normal liver tissues. In vitro, we explored the role of TXNIP in hepatocellular carcinoma progression via transfection of the pcDNA-3.1-TXNIP plasmid into SMMC7221 cells. Our results showed that the expression of TXNIP was significantly decreased in hepatocellular carcinoma tissues. Moreover, TXNIP over expression inhibited hepatocellular carcinoma cell proliferation and induced apoptosis by triggering mitochondrial-mediated ROS generation and activating MAPK pathways. This study provides insight into the molecular mechanisms of TXNIP overexpression in liver cancer cell survival and apoptosis and indicated that TXNIP may be a novel promising agent for liver cancer treatment.

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“…Ellagic acid has been shown to specifically induce apoptosis in cancer cells [13, 14, 18, 30–34] while having cytoprotective activity in non-transformed cells [2, 4, 10, 12, 19, 35]. To determine whether EA activated apoptotic pathways, we measured caspase-3 catalytic activities in cells treated with EA for 24 hours.…”

Section: Resultsmentioning

confidence: 99%

“…In non-transformed cells, EA is protective against oxidative insults [10–12]. In contrast, EA has anti-proliferative and apoptotic effects in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Cell type-dependent effects of ellagic acid on cellular metabolism

Boehning

Essien

Underwood

et al. 2018

Biomedicine & Pharmacotherapy

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Ellagic acid is a botanical polyphenol which has been shown to have numerous effects on cellular function. Ellagic acid can induce apoptosis and inhibit the proliferation of various cancer cell types in vitro and in vivo. As such, ellagic acid has attracted significant interest as a potential chemotherapeutic compound. One mechanism by which ellagic acid has been proposed to affect cellular physiology is by regulating metabolic pathways. Here we show the dose-dependent effects of ellagic acid on cellular energy production and downstream induction of the apoptotic program in HEK293, HeLa, MCF7, and HepG2 cells. At physiologically relevant doses, ellagic acid has pleiotropic and cell-type specific effects on mitochondrial function. At high doses ellagic acid can also influence glycolytic pathways and induce cell death. Our results demonstrate that ellagic acid can influence mitochondrial function at therapeutically relevant concentrations. The observed effects of ellagic acid on cellular respiration are complex and cell type-specific, which may limit the chemotherapeutic utility of this compound.

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Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity

Abstract: Our findings suggest that EA treatment attenuates GEN-induced nephrotoxicity, which may be ascribed to its antioxidant and anti-apoptotic properties.

Cited by 47 publications

References 52 publications

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic Disorders

TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation

Cell type-dependent effects of ellagic acid on cellular metabolism

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