Ellagic acid-Fe@BSA nanoparticles for endogenous H<sub>2</sub>S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Tian, Qingqing; An, Lin; Lin, Jiaomin; Yang, Shiping

doi:10.7150/thno.41882

Cited by 98 publications

(73 citation statements)

References 44 publications

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“…[ 13 ] These gas molecules act as messengers in the process of specific binding with multivalent transition metals, endowing many physiological functions in human bodies. [ 14 ] For example, H 2 S gas is reported to suppress the expression to catalase activity of tumors cells, [ 15 ] or to facilitate the reduction of Fe 3+ to Fe 2+ , [ 16 ] thus promoting the efficiency of CDT in the presence of H 2 O 2 . H 2 S also could aggravate the hypoxia to activate hypoxia‐activated prodrug to enhance chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

Yang

Luo

et al. 2020

Adv Funct Materials

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Nanocatalytic medicine has emerged as a promising method for the specific cancer therapy by mediating the interaction between tumor microenvironment biomarkers and nanoagents. However, the produced antitumor cell killing molecules, such as reactive oxygen species (ROS), by catalysis are insufficient to inhibit tumor growth. Herein, a novel kind of polyvinyl pyrrolidone modified multifunctional iron sulfide nanoparticles (Fe1−xS‐PVP NPs) is developed via a one‐step hydrothermal method, which exhibits high photothermal (PT) conversion efficiency (η = 24%) under the irradiation of 808 nm near‐infrared laser. The increased temperature further facilitates the Fenton reaction to generate abundant •OH radicals. More importantly, under an acidic (pH = 6.5) condition within tumor environment, the Fe1−xS‐PVP NPs can in situ produce H2S gas, which is evidenced to suppress the activity of enzyme cytochrome c oxidase (COX IV) in cancer cells, contributing to inhibit the growth of tumor. Both in vitro and in vivo results demonstrate that the H2S‐mediated gas therapy in combination with PT enhanced ROS achieves excellent antitumor performance, which can open up a new approach for the design of gas‐mediated cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

Yang

Luo

et al. 2020

Adv Funct Materials

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“…A variety of gas molecules may regulate particular cellular pathways and in turn influence cell proliferation, apoptosis/death, metabolism, and so on 19 - 21 . Similar to carbon monoxide (CO) and nitric oxide (NO), hydrogen sulfide (H 2 S), as an endogenous gaseous transmitter, is known to play a crucial role in physiological and pathophysiological processes 22 - 25 . Several key proteins corresponding to cellular pathways are likely to be sulfhydrated and form protein persulfides by H 2 S, so-called S-sulfhydration 26 , 27 .…”

Section: Introductionmentioning

confidence: 99%

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

et al. 2020

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Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current tumor treatment. The development of versatile drug delivery systems which present responsive characteristics to tumor microenvironment (TME) has been extensively carried out, but remains challenging. In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have been designed and prepared for co-delivery of ICG/TPZ molecules, denoted as ZSZIT, for H 2 S-amplified synergistic therapy. Methods: The ZSZ nanoparticles were characterized using SEM, TEM and XRD. The in vitro viabilities of cancer cells cultured with ZSZIT under normoxia/hypoxia conditions were evaluated by cell counting kit-8 (CCK-8) assay. In addition, in vivo anti-tumor effect was also performed using male Balb/c nude mice as animal model. Results: ZSZIT shows cascade PDT and hypoxia-activated chemotherapeutic effect under an 808nm NIR irradiation. Meanwhile, ZSZIT degrades under tumor acidic environment, and H 2 S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug. Both in vitro and in vivo studies demonstrate the H 2 S-sensitized synergistic antitumor effect based on cascade PDT/chemotherapy. Conclusion: This cascade H 2 S-sensitized synergistic nanoplatform has enabled more effective and lasting anticancer treatment.

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“…[ 152–154 ] Especially, the local temperature elevation can expedite the Fenton reaction rate and enhance the reaction degree for ROS production. [ 155–159 ] On this ground, we recently designed photothermal‐enhanced Fenton composite nanocatalysts for synergistic PTT and CDT against tumor, which were based on Fe 3 O 4 /GOD‐functionalized polypyrrole (PPy) nanoparticles (Figure 11b). [ 143 ] The GOD component initiated the catalytic conversion of glucose into H 2 O 2 , which was then catalyzed into hydroxyl radicals by the Fe 3 O 4 component as Fenton nanocatalysts.…”

Section: Chemodynamic Therapymentioning

confidence: 99%

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

et al. 2021

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Figure 3. a) Scheme for the constructed Fe(III)/TPPS nanosonosensitizer for synergistic sonotheranostics by RGD-enabled tumor targeting, downregulated SOD2 expression, GSH depletion, Fenton reaction-triggered hydroxyl radicals and SDT. Reproduced with permission. [38] Copyright 2019, Wiley-VCH. b) Schematic illustration of the design principle and mechanism of combinatorial SDT and immunotherapy, including nanosonosensitizer-enabled and SDT-induced antitumor immune responses and checkpoint blockade for tumor immunotherapy. Reproduced under the terms of the CC-BY Creative Commons Attribution 4.

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Ellagic acid-Fe@BSA nanoparticles for endogenous H₂S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Cited by 98 publications

References 44 publications

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

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Ellagic acid-Fe@BSA nanoparticles for endogenous H2S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Cited by 98 publications

References 44 publications

Photothermo‐Promoted Nanocatalysis Combined with H2S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

Photothermo‐Promoted Nanocatalysis Combined with H2S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy

Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics

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Ellagic acid-Fe@BSA nanoparticles for endogenous H₂S accelerated Fe(III)/Fe(II) conversion and photothermal synergistically enhanced chemodynamic therapy

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

Photothermo‐Promoted Nanocatalysis Combined with H₂S‐Mediated Respiration Inhibition for Efficient Cancer Therapy

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H₂S-amplified synergistic therapy