Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism

El-Shitany, Nagla A.; El-Bastawissy, Eman; El-desoky, Karema

doi:10.1016/j.intimp.2014.02.004

Cited by 121 publications

(76 citation statements)

References 46 publications

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“…3A), which is consistent with the previous report (Baldwin, 1996). Previous studies have also reported that flavonoids (Wall et al, 2013), proanthocyanidins (Hou et al, 2007), polysaccharides (Peng et al, 2014), and some polyphenolic compounds such as corilagin (Zhao et al, 2008), ellagic acid (El-Shitany et al, 2014), and gallic acid (Choi et al, 2009;Kim et al, 2006) inhibited pro-inflammatory genes expression through inhibition of AP-1 and NF-κB activation.…”

Section: Resultssupporting

confidence: 89%

Longan ( Dimocarpus longan Lour.) inhibits lipopolysaccharide-stimulated nitric oxide production in macrophages by suppressing NF-κB and AP-1 signaling pathways

Kunworarath

Rangkadilok

Suriyo

et al. 2016

Journal of Ethnopharmacology

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Section: Resultssupporting

confidence: 89%

Longan ( Dimocarpus longan Lour.) inhibits lipopolysaccharide-stimulated nitric oxide production in macrophages by suppressing NF-κB and AP-1 signaling pathways

Kunworarath

Rangkadilok

Suriyo

et al. 2016

Journal of Ethnopharmacology

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“…The protective role of ellagitannins and its metabolites against acute inflammation has been explored in in vivo and in vitro models (Umesalma and Sudhandiran, 2010;Ahad et al, 2014;El-Shitany et al, 2014) (Figure 3). Ellagic acid exhibited a potent anti-inflammatory effect against carrageenan-induced inflammation (El-Shitany et al, 2014).…”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

“…Ellagic acid exhibited a potent anti-inflammatory effect against carrageenan-induced inflammation (El-Shitany et al, 2014). The mechanisms by which ellagic acid protected against inflammation could be linked to the reduction of inflammatory molecules such as, nitric oxide (NO), malondialdehyde (MDA), interleukin-1 beta (IL-1β), tumor …”

Section: Anti-inflammatory Effectsmentioning

confidence: 99%

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Health benefits of walnut polyphenols: An exploration beyond their lipid profile

Sánchez-González

Ciudad

Noé

et al. 2017

Critical Reviews in Food Science and Nutrition

124

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Walnuts are commonly found in our diet and have been recognized for their nutritious properties for a long time. Traditionally, walnuts have been known for their lipid profile which has been linked to a wide array of biological properties and health-promoting effects. In addition to essential fatty acids, walnuts contain a variety of other bioactive compounds such as, vitamin E and polyphenols. Among common foods and beverages, walnuts represent one of the most important sources of polyphenols, hence, their effect over human health warrants attention. The main polyphenol in walnuts is pedunculagin, an ellagitannin. After consumption, ellagitannins are hydrolyzed to release ellagic acid, which is converted by gut microflora to urolithin A and

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“…The IL-10 increase is also demonstrated during treatment with anti-inflammatory agents like ellagic acid or meloxicam, while B cell-induced IL-10 secretion by Tregs or DCs is associated with recovery of Kawasaki Disease (KD), nonobese diabetes, MS, autoimmune thyroiditis (AT), etc. [110][111][112][113][114]. With respect to systemic lupus erythematous (SLE), both the percentage of circulating Breg cells and the ability to produce IL-10 were elevated; the percentage of Breg cells increased during SLE flares and decreased following disease remission [115].…”

Section: Principal Immune Conditionsmentioning

confidence: 99%

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

Mingomataj

Bakiri

2015

Clinic Rev Allerg Immunol

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The interleukin-10 (IL-10) is generally considered as the most important cytokine with anti-inflammatory properties and one of the key cytokines preventing inflammation-mediated tissue damage. In this respect, IL-10 producing cells play a crucial role in the outcome of infections, allergy, autoimmune reactions, tumor development, and transplant tolerance. Based on recent findings with regard to the mentioned clinical conditions, this review attempts to shed some light on the IL-10 functions, considering this cytokine as inherent inducer of the switching immunity. While acute infections and vaccinations are associated by IL-10 enhanced during few weeks, chronic parasitoses, tumor diseases, allergen-specific immunotherapy, transplants, and use of immune-suppressor drugs show an increased IL-10 level along months or years. With regard to autoimmune pathologies, the IL-10 increase is prevalently observed during early stages, whereas the successive stages are characterized by reaching of immune equilibrium independently to disease's activity. Together, these findings indicate that IL-10 is mainly produced during transient immune conditions and the persistent IL-10-related effect is the indication/prediction (and maybe effectuation) of the switching immunity. Actual knowledge emphasizes that any manipulation of the IL-10 response for treatment purposes should be considered very cautiously due to its potential hazards to the immune system. Probably, the IL-10 as potential switcher of immunity response should be used in association with co-stimulatory immune effectors that are necessary to determine the appropriate deviation during treatment of respective pathologies. Hopefully, further findings would open new avenues to study the biology of this "master switch" cytokine and its therapeutic potential.

show abstract

Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism

Cited by 121 publications

References 46 publications

Longan ( Dimocarpus longan Lour.) inhibits lipopolysaccharide-stimulated nitric oxide production in macrophages by suppressing NF-κB and AP-1 signaling pathways

Longan ( Dimocarpus longan Lour.) inhibits lipopolysaccharide-stimulated nitric oxide production in macrophages by suppressing NF-κB and AP-1 signaling pathways

Health benefits of walnut polyphenols: An exploration beyond their lipid profile

Regulator Versus Effector Paradigm: Interleukin-10 as Indicator of the Switching Response

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