Elucidating a Biological Role for Chromium at a Molecular Level

Vincent, John B.

doi:10.1021/ar990073r

Cited by 269 publications

(184 citation statements)

References 57 publications

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“…Cr(III) is considered to be a trace element essential for the proper functioning of living organisms [1][2][3][4][5][6] while Cr(VI) exerts toxic effects on biological systems. Occupational exposure to hexavalent Cr compounds leads to a variety of clinical problems 7,8 and Cr(VI) compounds toxicity derives from its ability to diffuse through cell membranes and oxidize biological molecules.…”

Section: Introductionmentioning

confidence: 58%

Silsesquioxane 3-n-Propylpyridinium chloride: a new polymer for the potentiometric analysis of Cr(VI) in electroplating and leather industry wastes

Muxel¹,

Jesus²,

Alfaya³

et al. 2007

J. Braz. Chem. Soc.

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Um novo polímero, cloreto de 3-n-propilpiridínio-silsesquioxano (SiPy + Cl -), foi utilizado na preparação de um eletrodo. Este eletrodo íon seletivo, formado de um bastão de grafite recoberto pelo polímero, foi construído e avaliado pela determinação de Cr(VI) em amostras de águas residuárias de indústrias de galvanoplastia e de couro. O eletrodo exibiu uma resposta Nernstiana para Cr(VI) entre as concentrações 3,1×10-6 e 1,8×10 -2 mol L -1 e limite de detecção de 2,8×10-6 mol L -1 (0,15 ppm). A resposta do eletrodo para Cr(VI) foi rápida (15 s) e o potencial independente do pH na faixa de 3,0 a 7,0. Os coeficientes de seletividade para diversos ânions mostram que o eletrodo apresenta um excelente desempenho. O sensor exibe um tempo de vida útil de 6 meses com boa reprodutibilidade. A determinação de Cr(VI) em águas residuárias de indústrias de galvanoplastia e de couro usando o sensor foi realizada com sucesso.A new polymer, silsesquioxane 3-n-propylpyridinium chloride (SiPy + Cl -), was used in the preparation of an electrode. The polymer coated graphite rod ion selective electrode for Cr(VI) was constructed and evaluated for the determination of Cr(VI) in samples of electroplating and leather industry wastes. This electrode exhibited a Nernstian response for Cr(VI) concentrations between 3.1×10 -6 and 1.8×10 -2 mol L -1 and a detection limit of 2.8×10 -6 mol L -1 (0.15 ppm). The response of the electrode for Cr(VI) was fast (15 s) and the independent potential of pH in the range of 3.0 to 7.0. The selectivity coefficients for several anions showed that the electrode presents excellent performance. The sensor exhibits a shelf-life of 6 months with good reproducibility. Determination of Cr(VI) in electroplating and leather wastes using the sensor was successfully achieved.

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Section: Introductionmentioning

confidence: 58%

Silsesquioxane 3-n-Propylpyridinium chloride: a new polymer for the potentiometric analysis of Cr(VI) in electroplating and leather industry wastes

Muxel¹,

Jesus²,

Alfaya³

et al. 2007

J. Braz. Chem. Soc.

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“…To date, very few studies have assessed the impact of essential trace elements on IVF, although sufficient stores are clearly needed for success [8]. Cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), molybdenum (Mo), and zinc (Zn) are essential for normal physiologic function and play significant roles in human [9][10][11][12] and overall mammalian reproduction [13]. However, few human data are available to describe the role of essential trace elements in IVF, and their impact remains inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

Ingle

Bloom

Parsons

et al. 2016

J Assist Reprod Genet

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Purpose A hypothesis-generating pilot study exploring associations between essential trace elements measured in follicular fluid (FF) and urine and in vitro fertilization (IVF) endpoints. Methods We recruited 58 women undergoing IVF between 2007 and 2008, and measured cobalt, chromium, copper, manganese, molybdenum, and zinc in FF (n = 46) and urine (n = 45) by inductively coupled plasma mass spectrometry (ICP-MS). We used multivariable regression models to assess the impact of FF and urine trace elements on IVF outcomes, adjusted for age, body mass index, race, and cigarette smoking.Results Trace elements were mostly present at lower concentrations in FF than in urine. The average number of oocytes retrieved was positively associated with higher urine cobalt, chromium, copper, and molybdenum concentrations. FF chromium and manganese were negatively associated with the proportion of mature oocytes, yet urine manganese had a positive association. FF zinc was inversely associated with average oocyte fertilization. Urine trace elements were significant positive predictors for the total number of embryos generated. FF copper predicted lower embryo fragmentation while urine copper was associated with higher embryo cell number and urine manganese with higher embryo fragmentation. No associations were detected for implantation, pregnancy, or live birth. Conclusions Our results suggest the importance of trace elements in both FF and urine for intermediate, although not necessarily clinical, IVF endpoints. The results differed using FF or urine biomarkers of exposure, which may have implications for the design of clinical and epidemiologic investigations. These initial findings will form the basis of a more definitive future study.

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“…Conversely, Cr III is thought to be an essential trace element for mammals because it is apparently involved in glucose and lipid metabolism. However, elucidating its function at a molecular level has proved to be problematic (Vincent 2000). The Food and Nutrition Board of the Institute of Medicine (IOM 1989) tentatively identified the estimated safe and adequate dietary intake (ESSADDI) for adults of chromium to be 50-200 lg Cr/d.…”

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confidence: 99%

Cadmium, Lead, and Chromium in Large Game: A Local-Scale Exposure Assessment for Hunters Consuming Meat and Liver of Wild Boar

Danieli

Serrani

Primi

et al. 2012

Arch Environ Contam Toxicol

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Heavy metals are ubiquitous in soil, water, and air. Their entrance into the food chain is an important environmental issue that entails risks to humans. Several reports indicate that game meat can be an important source of heavy metals, particularly because of the increasing consumption of game meat, mainly by hunters. We performed an exposure assessment of hunters and members of their households, both adults and children, who consumed wild boar (WB) meat and offal. We estimated the amount of cadmium, lead, and chromium in the tissues of WB hunted in six areas within Viterbo Province (Italy) and gathered data on WB meat and offal consumption by conducting specific diet surveys in the same areas. The exposure to cadmium, lead, and chromium was simulated with specifically developed Monte Carlo simulation models. Cadmium and lead levels in WB liver and meat harvested in Viterbo Province (Italy) were similar to or lower than the values reported in other studies. However, some samples contained these metals at levels greater then the EU limits set for domestic animals. The chromium content of meat or liver cannot be evaluated against any regulatory limit, but our results suggest that the amounts of this metal found in WB products may reflect a moderate environmental load. Our survey of the hunter population confirmed that their consumption of WB meat and liver was greater than that of the general Italian population. This level of consumption was comparable with other European studies. Consumption of WB products contributes significantly to cadmium and lead exposure of both adults and children. More specifically, consumption of the WB liver contributed significantly to total cadmium and lead exposure of members of the households of WB hunters. As a general rule, liver consumption should be kept to a minimum, especially for children living in these hunter households. The exposure to chromium estimated for this population of hunters may be considered to be safe. However, a specific and complete assessment of chromium speciation in relevant dietary and environmental situations should be conducted.

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Elucidating a Biological Role for Chromium at a Molecular Level

Cited by 269 publications

References 57 publications

Silsesquioxane 3-n-Propylpyridinium chloride: a new polymer for the potentiometric analysis of Cr(VI) in electroplating and leather industry wastes

Silsesquioxane 3-n-Propylpyridinium chloride: a new polymer for the potentiometric analysis of Cr(VI) in electroplating and leather industry wastes

Associations between IVF outcomes and essential trace elements measured in follicular fluid and urine: a pilot study

Cadmium, Lead, and Chromium in Large Game: A Local-Scale Exposure Assessment for Hunters Consuming Meat and Liver of Wild Boar

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