Elucidating encounters of atypical ductal hyperplasia arising in gynaecomastia

Abstract

ADH in gynaecomastia can be distinguished from UDH by morphological and immunohistochemical features. We also identified a subset of young patients (< 25 years) with extensive bilateral ADH. More studies are needed to characterize this patient subset more clearly.

Gynecomastia With Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ Associated With Invasive Breast Carcinoma in a Male Patient on Antiretroviral Therapy

“…The recent study by Wells et al of atypical ductal hyperplasia arising in gynecomastia demonstrated the usefulness of CK5/6 and ER staining in discriminating usual ductal hyperplasia from ADH and DCIS in gynecomastia. 5 Moreover, with diminishing reactivity for CK5/6 positive luminal epithelial cells in ADH compared with UDH, the authors concluded that ADH in this context may represent a transitional state in the evolution of DCIS in some cases but that if the pathway exists, it is not a well-utilized one. In contrast, Kornegoor et al suggest that gynecomastia does not seem to be an obligate precursor to breast cancer as it is a proliferation of 2 different cell types.…”

“…They included 25 cases of ADH with gynecomastia, 9 cases of DCIS (2 of which had concurrent ADH), and 36 cases of gynecomastia with usual ductal hyperplasia. 5 Moreover, while usual ductal hyperplasia and ADH as well as invasive and noninvasive breast carcinoma in males can be concurrent with gynecomastia, to date, no cases have shown ADH and DCIS with features of gynecomastia and associated invasive carcinoma. 1-7 Columnar cell-like change has been reported in a series of male breast resections, some of which showed gynecomastoid hyperplasia.…”

“…5 Moreover, while usual ductal hyperplasia and ADH as well as invasive and noninvasive breast carcinoma in males can be concurrent with gynecomastia, to date, no cases have shown ADH and DCIS with features of gynecomastia and associated invasive carcinoma. 1-7 Columnar cell-like change has been reported in a series of male breast resections, some of which showed gynecomastoid hyperplasia. 7 Columnar cell change, however, is not well evaluated in the context of the male breast, and some authors consider this lesion to be very rare in the male breast and likely to be noncontributory to carcinogenesis.…”

Atypical ductal hyperplasia in men with gynecomastia: what is their breast cancer risk?

“…If a patient undergoes surgery for gynecomastia, pathologic analysis of the excised tissue is generally recommended to rule out occult breast cancer or other incidental findings [1][2][3]. The incidence of atypical ductal hyperplasia (ADH) in gynecomastia specimens ranges from 0.4-5.4% [4][5][6].…”

Bilateral Atypical Ductal Hyperplasia with Microcalcifications in a Patient with Gynecomastia

“…To our knowledge, this is the first report of atypical ductal hyperplasia with microcalcifications in a male patient [ 4 ]. Consequently, insufficient evidence exists to support the hypothesis that this condition is a risk factor for male breast cancer, as it is for females.…”