Elucidating Sex Differences in Cerebral Aneurysm Biology and Therapy

Amenta, Peter S.; Medel, Ricky; Pascale, Crissey L.; Dumont, Aaron S.

doi:10.1161/hypertensionaha.116.07606

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…In line with previous studies [39][40][41], women are overrepresented in our cohort of patients affected by IAs. However, the proportions of females in the ruptured and unruptured IA subgroups are similar, which suggests that females are more likely to develop IAs but their aneurysms do not rupture more frequently.…”

Section: Discussionsupporting

confidence: 93%

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Morel

Hostettler

Spinner

et al. 2022

JPM

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Intracranial aneurysms (IAs) are usually asymptomatic with a low risk of rupture, but consequences of aneurysmal subarachnoid hemorrhage (aSAH) are severe. Identifying IAs at risk of rupture has important clinical and socio-economic consequences. The goal of this study was to assess the effect of patient and IA characteristics on the likelihood of IA being diagnosed incidentally versus ruptured. Patients were recruited at 21 international centers. Seven phenotypic patient characteristics and three IA characteristics were recorded. The analyzed cohort included 7992 patients. Multivariate analysis demonstrated that: (1) IA location is the strongest factor associated with IA rupture status at diagnosis; (2) Risk factor awareness (hypertension, smoking) increases the likelihood of being diagnosed with unruptured IA; (3) Patients with ruptured IAs in high-risk locations tend to be older, and their IAs are smaller; (4) Smokers with ruptured IAs tend to be younger, and their IAs are larger; (5) Female patients with ruptured IAs tend to be older, and their IAs are smaller; (6) IA size and age at rupture correlate. The assessment of associations regarding patient and IA characteristics with IA rupture allows us to refine IA disease models and provide data to develop risk instruments for clinicians to support personalized decision-making.

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Section: Discussionsupporting

confidence: 93%

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Morel

Hostettler

Spinner

et al. 2022

JPM

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“…25 This study had a female: male ratio of 1.8: 1, which is similar to the published international series. 25 However, some studies have shown an even higher prevalence of 3: 1 in favour of women. 26,27 There are regional variations in the incidence of SAH, a complication of untreated intracranial aneurysms, with the incidence higher amongst Finnish and Japanese populations.…”

Section: Discussionsupporting

confidence: 83%

Intracranial aneurysms in Ghanaian adults

D. Sarkodie,

B. Jimah,

H. Mohammed

et al. 2023

gmj

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Objective: To document the location, size, and multiplicity of intracranial aneurysms in Ghanaians who have undergone digital subtraction angiography (DSA) at a single centre in Accra, Ghana.Design: We conducted a retrospective observational review of the medical records of all patients diagnosed with intracranial aneurysms on DSASetting: Patients’ medical records at Euracare Advanced Diagnostic and Heart Centre were reviewed between March 2018 and March 2020.Participants: Thirty-one patients were identified with various intracranial aneurysms (IAs) within the study period. Patients’ ages, sex, and types of IAs were extracted using a checklist and analysed using Microsoft Excel for Windows 2016.Interventions: NoneMain outcome measures: The prevalence of types and distribution of intracranial aneurysms.Results: The age range of the patients was 26-76 years, with a mean age of 45.5±14.3 years. The mean age of men and women with IA was 45.5 ±15.9 years and 46.7 51.3±12.9 years, respectively. The most common IAs were located in the posterior communicating artery (PCOM) at 54.8% (95%CI: 36.0, 72.7), followed by the anterior communicating (ACOM), which constituted 32.3% (95%CI: 16.7, 51.4). The majority, 89.2% (33/37) of these aneurysms were less than 7mm in diameter. Single aneurysms were present in 25 (80.6%).Conclusion: The most common IAs were found in the PCOM and ACOM, and IAs tend to rupture at a younger age and smaller size among the Ghanaian adults examined. Early detection and treatment of IAs less than 7mm in diameter is recommended.

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“…Such data imply that estrogen may contribute to the biological process of IA. 24) On the contrary, protective aspirin (≥3 times/week) effect on SAH development was more noted in male than female IA patients. 25 , 26) Therefore, genetic factors and gender difference should be further evaluated in IA formation in the future work.…”

Section: Discussionmentioning

confidence: 97%

Genetic Risk Assessment of Elastin Gene Polymorphisms with Intracranial Aneurysm in Koreans

Jeon

Hong

Kim

et al. 2018

Neurol. Med. Chir.(Tokyo)

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Elastin encoded by elastin gene (ELN) is a crucial extracellular matrix protein responsible for arterial resilience. The objective of this study was to identify single nucleotide polymorphisms (SNPs) of ELN gene susceptible to intracranial aneurysm (IA) in Korean population. Two SNPs of ELN gene, rs2071307 (Gly422Ser) and rs2856728 (intron), were genotyped in 90 patients with IA and 90 age and frequency matched controls. Fisher’s exact test was conducted to evaluate allelic association with IA. Of the two SNPs in ELN gene, T allele of rs2856728 (intron) showed statistically significant association with increased development of IA (odds ratio [OR]: 2.34, 95% confidence interval [CI]: 1.44–3.81, P = 7.6 × 10−4). However, G allele of rs2071307 (Gly422Ser) had no significant association with the development of IA (OR: 1.27, 95% CI: 1.44–3.81, P = 0.607). Interestingly, the odds of having rs2856728 variant was approximately 2-fold higher in males than that in females (OR: 3.46 vs. 1.88, P < 0.05). However, none of SNPs showed difference between single and multiple IA in this study. This preliminary study implies that the rs2856728 variant in ELN gene polymorphisms might play crucial roles in the development and pathogenesis of IA in Korean population.

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Elucidating Sex Differences in Cerebral Aneurysm Biology and Therapy

Cited by 8 publications

References 10 publications

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

Intracranial aneurysms in Ghanaian adults

Genetic Risk Assessment of Elastin Gene Polymorphisms with Intracranial Aneurysm in Koreans

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