Elucidating the differences in pathogenicity between hepatitis E virus genotypes: The quest continues

Vercouter, Ann-Sofie; Meuleman, Philip

doi:10.1002/hep4.1152

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…There are 7 genotypes (G1–7) of this hepatotropic RNA virus [11]; G1 to G4 and G7 are capable of human infection [12]; genotypes 5 and 6 only infect animals [13]. G1 and G2 are exclusively human pathogens and responsible for waterborne outbreaks in developing countries [5]; G3 and G4 are enzootic in swine [14].…”

Section: Hepatitis E Virologymentioning

confidence: 99%

Clinical presentations of Hepatitis E: A clinical review with representative case histories

Chauhan

Webb

Ferguson

2019

Clinics and Research in Hepatology and Gastroenterology

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SummaryHepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. This review examines current understanding of the HEV. We illustrate typical clinical presentations, management strategies [(based upon guidelines from both the British Transplant Society (BTS) and European Association for the study of liver (EASL)] and outcomes of HEV infection in different cohorts of patients by highlighting select transplant and non-transplant patient cases, from one of the largest tertiary Hepatology centres in Europe.

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Section: Hepatitis E Virologymentioning

confidence: 99%

Clinical presentations of Hepatitis E: A clinical review with representative case histories

Chauhan

Webb

Ferguson

2019

Clinics and Research in Hepatology and Gastroenterology

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“…Genotype 1 and genotype 2 strains are strictly human pathogens, in contrast to zoonotic Gt 3 and 4. In particular, pigs are the main reservoir of HEV Gt 3, and its ability to cause zoonotic infections has been demonstrated several times (Baha et al, 2019; Smith et al, 2014; Vercouter & Meuleman, 2018). Similarly, consumption of contaminated deer, wild boar and rabbit products containing HEV‐infected organs was also suspected as cause of human Gt 3 cases (Khuroo et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis E virus in Cuba: A cross‐sectional serological and virological study in pigs and people occupationally exposed to pigs

Villalba

Snoeck

Lay

et al. 2022

Zoonoses and Public Health

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Surveillance of hepatitis E virus (HEV) in risk groups is an important strategy to monitor its circulation pattern and to timely detect changes thereof. The aims of this crosssectional study were to estimate the prevalence of HEV infections in pigs and humans from different regions of the country, to identify risk factors for increasing anti-HEV IgG prevalence and to characterize HEV strains. The presence of anti-HEV antibodies was assessed by commercial ELISA in serum samples from the general population, farm and slaughterhouse employees, as well as pigs sampled in the three regions of Cuba from February to September 2016. Overall, individuals with occupational exposure to swine or swine products (70/248, 28.2%) were 4 times more likely to be seropositive compared to the general population (25/285, 8.7%; OR: 4.18; p < .001).Within the risk group, risk factors included age, number of years working in a professional activity with direct exposure to swine, geographic region and distance between residence and closest professional swine setting, while wearing gloves had a protective effect. Prevalence of total anti-HEV antibodies in swine was 88.2% (165/187) and HEV RNA was detected by real-time RT-PCR in 9.2% (16/173) swine stools. All HEV strains sequenced clustered within genotype 3. Some strains clearly belonged to subtype 3a, while another group of strains was related with subtypes 3b and 3 k but partial HEV sequences did not allow unequivocal subtype assignment. These findings suggest that the high HEV exposure in Cuban individuals with swine-related occupations could be due to enzootic HEV in certain regions, direct contact with infectious animals or their products as well as environmental contamination.

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Elucidating the differences in pathogenicity between hepatitis E virus genotypes: The quest continues

Cited by 2 publications

References 13 publications

Clinical presentations of Hepatitis E: A clinical review with representative case histories

Clinical presentations of Hepatitis E: A clinical review with representative case histories

Hepatitis E virus in Cuba: A cross‐sectional serological and virological study in pigs and people occupationally exposed to pigs

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