Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology

Lei, Yu; Gai, Yun

doi:10.2147/dddt.s409530

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Yu, etc. [35] found that inhibiting mTOR phosphorylation also cut the expression of Bcl-2 protein in animal colon cancer model experiments in vivo and in vitro. Chen et al [36] found ARNTL (a cancer gene) may adversely affect the Akt/mTOR pathway in the tongue squamous cell carcinoma model, thereby enhancing autophagy induction, as well as the expression of Bcl-2 drops.…”

Section: Discussionmentioning

confidence: 98%

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia

Li,

Zhang,

Huang

et al. 2023

Neurochem Res

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White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter development in neonatal rats with WMD. We investigated the effect of inflammation on oligodendrocyte development in P0 neonatal rats by intracerebellar injection of LPS, and collected brain tissue at P2 and P5. Immunohistochemical and immunofluorescence staining were used to evaluate white matter damage, while immunofluorescence staining, terminal deoxynucleotidyl transferase dUTP nick end labeling analysis (TUNEL), and western blotting were used to evaluate autophagy and apoptosis. First, we observed that white matter development was arrested and white matter fiber maturation was impaired in LPS-inflicted pups compared with those in the sham-operated group. Second, treatment with SC79 reduced the levels of LC3II, caspase 3, caspase 9, and Bax/Bcl-2 and increased the levels of p62, p-Akt, and p-mTOR in the brain tissue of neonatal rats. Finally, SC79 treatment inhibited OPC apoptosis by increasing the binding of Beclin 1 to Bcl-2, which promoted OPC differentiation and maturation. However, the opposite results were observed after rapamycin administration. Taken together, our results suggest that SC79 can inhibit the abnormal apoptosis of OPCs caused by excessive autophagy through the Akt/mTOR pathway and that SC79 is a potential therapeutic agent for WMD in preterm infants.

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Section: Discussionmentioning

confidence: 98%

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia

Li,

Zhang,

Huang

et al. 2023

Neurochem Res

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“…Agrimonolide is a natural compound isolated from Agrimonia pilosa Ledeb, a traditional Chinese medicinal herb with important anti-inflammatory, anticancer and antioxidant activities [ 47 , 48 , 49 , 50 ]. It has been reported that agrimonolide significantly inhibited the proliferation, migration and invasion of A2780 and SKOV-3 cells and also promoted apoptosis in these cells.…”

Section: Slc7a11 Modulation By Natural and Synthetic Compounds In Ova...mentioning

confidence: 99%

Role of SLC7A11/xCT in Ovarian Cancer

Fantone,

Piani,

Olivieri

et al. 2024

IJMS

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Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology. Solute Carrier Family 7 Member 11 (SLC7A11, also known as xCT) is the functional subunit of the Xc− system, an anionic L-cystine/L-glutamate antiporter expressed on the cell surface. SLC7A11 expression is significantly upregulated in several types of cancers in which it can inhibit ferroptosis and favor cancer cell proliferation, invasion and chemoresistance. SLC7A11 expression is also increased in ovarian cancer tissues, suggesting a possible role of this protein as a therapeutic target. In this review, we provide an overview of the current literature regarding the role of SLC7A11 in ovarian cancer to provide new insights on SLC7A11 modulation and evaluate the potential role of SLC7A11 as a therapeutic target.

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Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: Insights from network pharmacology and molecular docking

Wu,

Gao,

Shen

et al. 2024

Journal of Ethnopharmacology

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Elucidating the Mechanism of Agrimonolide in Treating Colon Cancer Based on Network Pharmacology

Cited by 4 publications

References 35 publications

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia

Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia

Role of SLC7A11/xCT in Ovarian Cancer

Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: Insights from network pharmacology and molecular docking

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