2024
DOI: 10.3390/cells13181592
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Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging

Pawel Kordowitzki

Abstract: The field of reproductive biology has made significant progress in recent years, identifying specific molecular players that influence oocyte development and function. Among them, sirtuin 3 (SIRT3) has attracted particular attention for its central role in mediating mitochondrial function and cellular stress responses in oocytes. So far, studies have demonstrated that the knockdown of SIRT3 leads to a decrease in blastocyst formation and an increase in oxidative stress within an embryo, underscoring the import… Show more

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