Elucidation and Prediction of Molecular Mechanisms and Associated Pathways of the Prostaglandin-endoperoxide Synthase-2 as a Common Key Gene for Diabetes and Cachexia: Bioinformatics Strategies

Abstract

Cachexia and diabetes both feature severe weight loss as a phenotype, and both diseases share several gene and protein abnormalities. This study investigates the PTGS2 gene as a common key gene for diabetes and cachexia. A variety of biological databases and enrichment approaches were used to explore this gene. Probable genes and substances that could be used to address disease symptoms were identified using STICH, a protein-protein, and protein-drug interactions. It was also established that PTGS2 is strongly linked to the pharmacology of the ibuprofen route of action. These findings and annotations will aid in further research into the therapeutic option of targeting the PTGS2 gene in the treatment of both disorders.