Elucidation of larvicidal potential of metallic and environment friendly food-grade nanostructures against Aedes albopictus

Effect of Curcuma longa rhizome extract and curcumin against laboratory-reared Aedes Aegypti (Diptera: Culicidae) larvae: Alterations of cell ultrastructure and immunoreactivity of octopamine and tyramine in the midgut

“…The present study found LC 50 and LC 90 values of curcumin were 1.522 ppm (95% CI = 1,121 -1,994 ppm) and 4.074 ppm (95% CI = 2,949 -7,110 ppm) respectively. The results of this study showed that the LC 50 value of curcumin was lower than that of de Souza et al [13] and Ahmed et al [31] reported because of differences in research methods. In short, in the study of de Souza et al [13] , curcumin was mixed with other substances, namely sucrose and D-mannitol.…”

“…In addition, nuclear pyknosis was also found which is a characteristic of cells undergoing apoptosis and necrosis. [31] Other researchers, Wang et al [35] in China reported that honokiol extract from the seeds of Magnolia denudate can damage the nuclear membrane of the midgut epithelial cells in Ae. aegypti and also found destroyed cellular components of the midgut and various organelle debris in the cytoplasm.…”

“…aegypti. Ahmed et al [31] in Pakistan reported that LC 50 and LC 90 values of FG-Cur E-III.50 polymeric nanocapsules against Ae. Albopictus larvae were 3.8 mg/L and 9.33 mg/L respectively.…”

“…aegypti. In the research of Ahmed et al [31] nanoparticles were used that could interfere with the toxicity of curcumin so that the larvae could survive. The reason that allows the crude extract of C. longa to have lower larvicidal activity compared to the pure extract is because that the active substances in the crude extract compete with each other.…”

“…In addition, large amounts of Ca 2+ are excreted into the cytoplasm and cause cell necrosis. [31] Curcumin also has an effect on the octopaminergic system in Ae. Aegypti larvae.…”