Elucidation of mass transfer mechanisms in pellet formation by spheronization

Evers, Maria; Mattusch, Amelie; Weis, Dominik; Aristizábal, Edwin Fabián García; Antonyuk, Sergiy; Thommes, Markus

doi:10.1016/j.ejpb.2021.01.013

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Raw material is the material basis for the preparation of pellets via the extrusion rounding method, and the extrudate, as the precursor of pellets, has a direct impact on the molding quality of pellets. The literature research [3][4][5][6][7][8][9][10][11] shows that the smoother the surface of the extrudate, the better the molding quality of the pellet, which is an important guiding significance for the preparation of pellets via the extrusion and rounding method. Researchers in traditional Chinese medicine basically follow the above theory when conducting studies of pellets found in traditional Chinese medicine [12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…When preparing pellets with pure microcrystalline cellulose (MCC) as the raw material, it is widely believed that the smoother the surface of the extrusion, the better the quality of the pellets prepared. The pellets prepared with a smooth extrusion surface have a high yield, good roundness, and a small particle size distribution [3][4][5][6][7][8][9]. Using different pellet preparation techniques also showed that the pellets obtained from extrudates with smooth surfaces had larger particle size, higher density, better fluidity, and characteristics of slow release and controlled release [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Extrudate-Based Textural Properties on Pellet Molding Quality

Tian,

Li,

et al. 2023

Pharmaceuticals

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As the precursor of pellets, the extrudate has a direct impact on the molding quality of the pellets. Therefore, the correlation between the surface roughness of the extrudates and the molding quality of pellets with pure microcrystalline cellulose (MCC) formulations and those containing traditional Chinese medicine (TCM) formulations was explored. MCC was used as a pelleting agent, mixer torque rheometry (MTR) was used to guide the optimal dosage of the wetting agent, and TCM extracts (drug loadings of 20% to 40%) were selected as model drugs to prepare the extrudates and pellets under the same extrusion spheronization process conditions. The surface roughness and texture parameters of extrudates were analyzed via a microscope and texture analyzer, respectively, and the quality of pellets was evaluated. The extrudate roughness of the pure MCC prescription decreased and then increased with increasing water addition, while the extrudate roughness of the prescription containing TCM extracts tended to increase and then decrease. The addition of water affected the extrudate properties, with TCM extract molecules filling gaps in the MCC structure, leading to rough surfaces. The extrudate roughness of the TCM prescriptions was significantly greater than that of the pure MCC prescriptions at optimal water addition levels, resulting in ideal pellets.

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