Elucidation of Mechanism(s) of the Nocturnal Rise of Testosterone in Men

Judd, Howard L.; Parker, Donal C.; Rakoff, Jeffrey S.; Hopper, Bill R.; Yen, S. S. C.

doi:10.1210/jcem-38-1-134

Cited by 89 publications

(34 citation statements)

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“…The absence of a consistent increase in the mean sleep T concentration compared with waking in the adult men in this study has been extended to additional subjects in a recent report from this laboratory.3 Although a nocturnal rise in T was found in four subjects reported by Judd, Parker, Rakoff, Hopper, and Yen (41), there were few waking samples obtained to compare adequately to the mean T concentrations during sleep. Although a nocturnal rise in T occurs in some adult men, it is not a consistent phenomenon, nor does it uniformly result in higher mean sleep T concentrations compared with waking.…”

Section: Resultsmentioning

confidence: 47%

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Boyar¹,

Rosenfeld²,

Kapen³

et al. 1974

J. Clin. Invest.

305

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A B S T R A C T Plasma luteinizing hormone (LH) and testosterone (T) were measured by radioimmunoassay in nine pubertal boys and three sexually mature young men at 20-min intervals for 24 h. Plasma LH and T were also measured in one boy during a delayed sleep onset study. Polygraphic monitoring was carried out to identify precisely sleep onset, wakefulness, and specific sleep stages. In all nine pubertal boys the plasma T concentration fluctuated and was significantly higher during normal nocturnal sleep as compared to daytime waking. This increased T secretion during sleep was temporally linked to the characteristic pubertal sleep augmentation of LH secretion. To define further the relationship of this increased T secretion to sleep, plasma LH and T were also measured in three of the pubertal boys after acute (1-day) reversal of the sleepwake cycle. One of these boys was also studied after 3 days of sleep-wake cycle reversal. The results of these studies showed that plasma T was now augmented during the reversed daytime sleep period; the mean T concentrations during this period were significantly higher (P < 0.001) than during nocturnal waking in all four studies. Measurement of plasma LH and T in the three sexually mature young men showed episodic secretion of LH and T during both waking and sleep periods; there was no consistent significant augmentation of LH or T secretion during sleep. This study demonstrates that (a) in normal pubertal boys and sexually mature young men plasma T fluctuates epi-A preliminary portion of this work has been reported as an abstract (1973. J. Clin. Invest. 52: 11a).Received for publication 19 October 1973 and in revised form 26 February 1974. sodically; (b) there is marked augmentation of T secretion during sleep in pubertal boys, which is dependent on increased LH secretion; (c) this pubertal LH-T secretory "program" is dependent on sleep, since it shifts with delayed sleep onset and reversal of the sleep-wake cycle; and (d) this demonstrable tropic effect of LH on T is evident only during puberty, since sexually mature young men fail to show any consistent relationship between LH and T secretion either awake or asleep. INTRODUCTIONRecent use of the combination of plasma sampling at frequent intervals, sensitive and specific radioimmunoassays, and polygraphic recording of sleep has led to a revised perspective of hormone-secretory dynamics. These procedures, employed throughout the complete 24-h sleep-wake cycle, allowed the recognition of the episodic secretion of cortisol (1-3), ACTH (4, 5). luteinizing hormone (LH)1 (6-13) and follicle-stimulating hormone (FSH) (8,11,12) in adult men and women. The polygraphic monitoring of sleep showed the important role of sleep in the secretion of human growth hormone (14-17), human prolactin (18-20), LH and FSH in normal pubertal girls (21-24), and LH in pubertal boys (22,23).

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Section: Resultsmentioning

confidence: 47%

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Boyar¹,

Rosenfeld²,

Kapen³

et al. 1974

J. Clin. Invest.

305

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“…Recently, Judd et al (1978) reported that prolactin responses to dopamine were highly correlated with serum estrogen levels. In the present study, both serum estradiol levels and prolactin responses were higher in women than in men (Table 2), which strongly suggested that there might be some relationship between the two.…”

Section: Discussionmentioning

confidence: 99%

Effects of domperidone on serum prolactin levels in human beings.

et al. 1980

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Effects of domperidone, a dopaminergic antagonist, on serum prolactin levels were studied in 6 normal men and 6 normal cyclic women at the different phases of their menstrual cycles (i.e., the follicular, the preovulatory and the luteal phases). Domperidone (10 mg, i.v.) caused significant increases in serum prolactin in all cases within 15 min after the injection. The prolactin response was significantly (p<0.01) higher in women than in men, and there was no significant difference in the prolactin responses among the three phases of the menstrual cycles. These results indicate that domperidone may be an effective stimulator of serum prolactin secretion in human beings.

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“…Cortisol levels were quantified by a previously described radioimmunoassay [17]. Measurements of the steroid hormones 17PO, A, DHEA and T were also made using previously described assays [18].…”

Section: Methodsmentioning

confidence: 99%

Increased adrenocortical responsiveness to exogenous ACTH in oral contraceptive users

et al. 1986

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To evaluate the effects of changing steroid milieu on adrenocortical function, basal levels and responses of cortisol, 17-hydroxyprogesterone (17PO), androstenedione (A), dehydroepiandrosterone (DHEA), and testosterone to exogenous synthetic ACTH were investigated in six normal women during the early follicular (EF) and midluteal (ML) phases of the menstrual cycle and in five women on an oral contraceptive (OC) agent (35 micrograms ethinyl estradiol and 1 mg ethynodiol diacetate, Demulen). Baseline serum steroid and cortisol binding globulin (CBG) levels were measured on days 3-7 and 21-23 of the menstrual cycle in the normal subjects and on days 3-7 of OC treatment cycles. ACTH stimulation (10 micrograms m-2 i.v. bolus) was performed following dexamethasone suppression (0.5 mg p.o. q 6 h X 4). Basal levels of cortisol and CBG as well as cortisol responses to ACTH were increased in OC users relative to normal women tested during both the EF and ML phases of the cycle. In addition, 17PO levels were increased during the ML phase both before and following dexamethasone suppression compared to levels present in the EF phase and in OC users, no doubt because of increased ovarian steroidogenesis.

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Elucidation of Mechanism(s) of the Nocturnal Rise of Testosterone in Men

Cited by 89 publications

References 0 publications

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

Effects of domperidone on serum prolactin levels in human beings.

Increased adrenocortical responsiveness to exogenous ACTH in oral contraceptive users

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