ELUCIDATION OF THE EARLY EVENTS CONTRIBUTING TO ZYMOSAN-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME USING MIP-1α, C3 KNOCKOUT, AND C5-Deficient MICE

Mahesh, J; Daly, J.M.; Cheadle, William G.; Kotwal, Girish J.

doi:10.1097/00024382-199911000-00003

Cited by 23 publications

(12 citation statements)

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“…Since the cells appeared lysed and the nucleus could not be differentiated, cell staining for specific esterases for neutrophil and macrophages was done in an attempt to differentiate between cell populations in the zymosantreated animals. In agreement with a previous observation (40), in all the shamtreated animals we confirmed the presence of 90% mononuclear cells in the peritoneal cavity along with 10% neutrophils. On the contrary, the zymosantreated samples could not be differentiated due to excessive phagocytosis and lysis of cells.…”

Section: Effect Of Epo Treatment On Inflammatory Response In the Perisupporting

confidence: 93%

Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice*

Cuzzocrea

Paola

Mazzon

et al. 2006

Critical Care Medicine

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Section: Effect Of Epo Treatment On Inflammatory Response In the Perisupporting

confidence: 93%

Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice*

Cuzzocrea

Paola

Mazzon

et al. 2006

Critical Care Medicine

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“…The zymosan model of peritonitis was also believed to be a sterile model of inflammation, but studies have shown that the organ dysfunction seen in high-dose zymosan models is dependent on bacterial translocation. 15,16 In our low-dose zymosan model, we still saw translocation of bacteria into the peritoneal cavity, although the number of colony-forming units was low and resolved rapidly.…”

Section: Discussionmentioning

confidence: 83%

A Low-Morbidity Murine Model of Peritonitis

Cooper

Yao²,

Mccauley³

et al. 2002

Diseases of the Colon &Amp; Rectum

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In this model of bacterial peritonitis in mice, we have demonstrated how the peritoneal cavity can resolve a relatively localized inflammatory insult within 96 hours of induction. This response is characterized by a cellular influx of predominantly neutrophils and macrophages and by pronounced oxidative activity. We will use this in vivo model to characterize aspects of the pathobiology and treatment of peritonitis.

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“…Also, C5 and its split products were not required for pulmonary clearance Bordetella bronchoseptia in vivo (Pishko et al, 2004). Furthermore, genetically C5-deficient mice are less susceptible to mortality and organ damage induced by zymosan (Nieuwenhuijzen et al, 1995;Mahesh et al, 1999). These studies suggest that C5 may not be essential to all host responses during inflammation and sepsis.…”

Section: Introductionmentioning

confidence: 98%