Elucidation of the Structure of Organic Compounds by Thermal Fragmentation

Simon, W.; Kriemler, P.; Voellmin, J. A.; Steiner, H.

doi:10.1093/chromsci/5.2.53

Cited by 49 publications

(11 citation statements)

References 9 publications

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“…Pyrolysis of a purified sample of this substance showed it to be chemically distinct from the type 111 antigen. This represents the first report of additivity of biological pyrograms, although it had been reported for pyrograms of relatively simple substances (Simon et al 1967). Huis In't Veld et al (1973) hypothesized that additivity is probably restricted to situations where large amounts of characteristic material are involved since small amounts would inevitably become caught up in secondary reactions leading to non-specific pyrolysis products.…”

Section: Applications To Bacteriologymentioning

confidence: 79%

“…Despite the great promise shown by this development it was thought that the high energy electron impact ionization processes were eliminating information on the chemical composition of the samples-even though this is theoretically available from the pyrolysis process (Simon et al 1967). The use of ionization techniques causing negligible fragmentation, such as field ionization (Beckey 197 1) or low voltage electron impact ionization (Field & Hastings 1956), promised to eliminate this problem.…”

Section: Pyrolysis Mass Spectrometrymentioning

confidence: 99%

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The Application of Pyrolysis Techniques to the Identification of Micro‐organisms

Gutteridge

Norris

1979

Journal of Applied Bacteriology

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Section: Applications To Bacteriologymentioning

confidence: 79%

Section: Pyrolysis Mass Spectrometrymentioning

confidence: 99%

The Application of Pyrolysis Techniques to the Identification of Micro‐organisms

Gutteridge

Norris

1979

Journal of Applied Bacteriology

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“…Also, catalytic effects have not been observed when using ferromagnetic conductors of different composition (Jones and Moyles, 1961). Pyrolysis results were not changed by coating the conductors with gold or platinum (Simon et al, 1967).…”

Section: Aiche Journalmentioning

confidence: 96%

Novel microreactor with quench system for kinetic study of propane pyrolysis

1988

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A novel microreactor with a rapid direct quench system was developed to study fast hydrocarbon pyrolysis reactions. Heating of reactants inside the reactor was achieved by a Curie Point Pyrolyser. The propane pyrolysis reaction was studied at four different temperature levels: 600, 700,800 and 900°C. Pyrolysis times were varied from 0 to 2 s between 600 to 800°C and from 0 to 1 s at 900°C. The primary reaction products were methane, ethylene, hydrogen and propylene. Using a developed and very effective quench technique increased the production of olefins and reduced the formation of methane. A first-order kinetic analysis performed on the experimental data between 600 and 700°C yielded an activation energy of 216 kJ/mol, which is in the range of other researchers.

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“…High-frequency (H-F) induction heating is a pyrolysis technique that uses a ferromagnetic alloy and a H-F induction coil [19,20,21]. The ferromagnetic alloy is placed in an electromagnetic field with a H-F generated using a pyrolyzer, and the alloy is heated to its Curie temperature.…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Heating Extraction Method for Sensitive Drug Analysis in Human Nails

Takahashi

Kobayashi²,

Kobayashi³

et al. 2018

Molecules

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Background: A simple, sensitive, and rapid extraction method based on high-frequency (H-F) heating was developed for drug analysis in human nails. Methods: A human nail was placed in a glass tube with an extraction solvent (methanol and 0.1% formic acid; 7:3, v/v), and a ferromagnetic alloy (pyrofoil) was wrapped in a spiral around the glass tube. Then, the glass tube was placed in a Curie point pyrolyzer, and a H-F alternating voltage (600 kHz) was applied. The sample and extraction solvent were heated at the Curie temperature for 3 min. Different Curie temperatures were applied by changing the pyrofoil (160 °C, 170 °C, 220 °C, and 255 °C). Results: The caffeine in the nail was effectively and rapidly extracted into the extraction solvent with the pyrofoil at 220 °C. The peak area obtained for the caffeine using liquid chromatography mass spectrometry (LC-MS/MS) was five times that of what was obtained after conventional ultrasonic irradiation extraction. Because the extraction uses high-pressure and high-temperature conditions in a test tube, the drugs that were strongly incorporated in nails could be extracted into the solvent. The amount of caffeine extracted was independent of the size of the pieces in the sample. Conclusions: Therefore, the sensitive determination of target drugs in nails is possible with rapid (20 min, including H-F extraction for 3 min) and simple sample preparation. The developed method was applied to a nail from a patient with hypertension.

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Elucidation of the Structure of Organic Compounds by Thermal Fragmentation

Cited by 49 publications

References 9 publications

The Application of Pyrolysis Techniques to the Identification of Micro‐organisms

The Application of Pyrolysis Techniques to the Identification of Micro‐organisms

Novel microreactor with quench system for kinetic study of propane pyrolysis

High-Frequency Heating Extraction Method for Sensitive Drug Analysis in Human Nails

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