In this paper, we propose an interference mitigation method to suppress the downlink interference in multi‐macrocell/femtocell networks, and analytically evaluate the interference mitigation and average rate performances. Specifically, the proposed interference mitigation method consists of three steps: frequency partitioning, cell partitioning, and sub‐band allocation. In the frequency partitioning step, the whole downlink frequency band is divided into nine non‐overlapping sub‐bands. In the cell partitioning step, each macrocell is divided into four macrocell regions and three femtocell regions for macrocells' and femtocells' communications, respectively. In the sub‐band allocation step, each macrocell or femtocell region is allocated a sub‐band to guarantee that any two neighboring macrocell/femtocell regions use different sub‐bands. Conducted simulation results show that the proposed method is effective in mitigating the downlink interference and improving the average downlink per‐channel rate in multi‐macrocell/femtocell networks. In summary, the major contribution of the proposed interference mitigation method is that the downlink interference can be mitigated without cooperation between macrocells and femtocells, while the full frequency utilization of the macrocell is achieved. Copyright © 2016 John Wiley & Sons, Ltd.