EM.P.1.06 Extracellular matrix metalloproteinase protein inducer (EMMPRIN/CD147) regulates myoblast differentiation through an MMP-mediated control of TGFb activity

Attia, Mickaël; Huet, Eric; Gawrzak, Sylwia; Ménashi, Suzanne; Martelly, Isabelle

doi:10.1016/j.nmd.2009.06.027

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2010

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“…76 Attia and colleagues reported that EMMPRIN inhibited differentiation of myoblasts by an MMP-dependent activation of TGFb, suggesting that EMMPRIN inhibition may represent a novel strategy in the treatment of muscular degenerative disorders. 77 The potential of therapeutic strategies targeting CD147 and CD44 to prevent prostate cancer metastasis and to overcome drug resistance has been reported. 78 Xie et al 79 indicated the involvement of EMMPRIN in the early stage of tooth germ development and morphogenesis, possibly by regulating the expression of MMP genes.…”

Section: Research and Reports In Biology Downloaded From Https://wwwmentioning

confidence: 99%

Matrix metalloproteinases – an overview

Sekhon¹

2010

RRB

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Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound zinc-dependent endopeptidases that have the combined capacity to degrade all the components of the extracellular matrix. These enzymes have a common zinc-binding motif (HEXXHXXGXXH) in their active site and a conserved methionine turn following the active site. MMP enzymes are strongly involved in a kaleidoscope of normal, pathological, physiological, and biological processes such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. MMPs play a significant role in vascular remodeling. Broad-spectrum metalloproteinase inhibitors as potential therapeutics have been developed to explore the involvement of MMPs in various diseases.

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Section: Research and Reports In Biology Downloaded From Https://wwwmentioning

confidence: 99%