The Microinstrumentation Lab group at Simon Fraser University (SFU) develops biomedical nano-and micro-devicebased microinstrumentation by combining integrated materials and interconnect technologies with a modular systems approach. A major focus of our research is the development and application of disparate materials, including novel nanomaterials developed in our laboratory, to discrete components, combined with integration and interconnection standards that are designed to be generally applicable to multiple systems in our lab. In this overview, we present a sample of these technologies that have been developed by our lab since its inception, and demonstrate use of these technologies in both discrete components and modular systems towards the realization of complex bio-microinstruments for an ever-expanding group of collaborative projects in biology and biomedicine.