2022
DOI: 10.1039/d2nj02981b
|View full text |Cite
|
Sign up to set email alerts
|

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H2O2-sensitive release and potency against infectious bacteria

Abstract: The problems caused by the use of pharmaceutical compounds have led to the development of targeted drug delivery systems. Most of the introduced systems have been studied in the field...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
9
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
7
1

Relationship

5
3

Authors

Journals

citations
Cited by 11 publications
(9 citation statements)
references
References 82 publications
0
9
0
Order By: Relevance
“…This gradual release validates the interaction of iodine with the ZIF-7 framework. 83 Also, we reasoned that under acidic conditions, ZIF-7 degradation is connected with benzimidazole protonation, which is related to the breaking of the coordination bond between Zn 2+ ions and benzimidazole, causing the adsorbed iodine to dissociate from the ZIF-7 surface. 22 Fig.…”
Section: In Vitro Iodine Release and Stabilitymentioning
confidence: 99%
“…This gradual release validates the interaction of iodine with the ZIF-7 framework. 83 Also, we reasoned that under acidic conditions, ZIF-7 degradation is connected with benzimidazole protonation, which is related to the breaking of the coordination bond between Zn 2+ ions and benzimidazole, causing the adsorbed iodine to dissociate from the ZIF-7 surface. 22 Fig.…”
Section: In Vitro Iodine Release and Stabilitymentioning
confidence: 99%
“…One of the applications that can be achieved in this way is the antibacterial property, which can be given to ZIFs by loading them with antibacterial materials. 12,13 In addition to this issue, as civilizations have developed, health care has garnered a great deal of attention, and a great deal of research has been conducted to enhance and resolve its connected issues. 14 Concurrently, multidrug resistance of microorganisms is a topic that has touched all aspects of contemporary life, particularly the medical field.…”
Section: Introductionmentioning
confidence: 99%
“…Compared to noble metals, supported Ni nanoparticle (NP) catalysts are more desirable due to their high selectivity, promising activity, cheaper price, and increased abundance. , Although the bare Ni NPs often have accompanied by disadvantages such as low stability (coalescence/sintering phenomenon) in high temperatures and poor performance at low temperatures, in order to overcome such problems, it is proposed to use the second metal due to the reinforcing synergistic effects , and choose suitable support that contains high dispersion potential or defect sites to create good interaction and electron transfer between the active metal and support. So far, various supports, including Al 2 O 3 , ZrO 2 , CeO 2 , zeolites, MgO, hydrotalcites, and natural clays, have been investigated due to some of their good properties. , The efficiency of CO 2 methanation often did not stay satisfactory in reaction conditions for the mentioned supports because of the temperature increase and subsequently the sintering process of nickel particles in them, which decreased the performance and selectivity of the catalyst during the reaction. ,, Metal–organic frameworks (MOFs) have proven to be promising catalysts or supports/precursors in a variety of applications, including gases conversion, , separation and storage, , energy, , sensing, , magnetics, , biomedicine, and antibacterial, due to a series of their unique features, containing porous and adjustable structures with defect sites, functional groups, and a high surface area that provide the potential for good interaction and dispersion of catalytic NPs with the substrate. Also, another valuable feature of MOFs is the encapsulation of metal particles into their nanopores, therefore controlling the size and morphology of metal NPs and preventing their aggregation. , To the best of our knowledge, MOFs were used for the first time by Zhen et al as emerging catalysts for CO 2 conversion to CH 4 in 2015 .…”
Section: Introductionmentioning
confidence: 99%