This paper identifies challenges for Computer-Supported Collaborative Learning at Work (CSCL@Work) by arguing that learning at work transcends our current understanding of learning as derived either from school learning or from current practices in adult education.The paper develops a number of themes defining a conceptual framework for CSCL@Work including the following: distributed cognition, integration of problem framing and solving, communities of interest, and meta-design, cultures of participation, and social creativity as approaches to learning when the answer is not known. It illustrates the framework with two narratives, identifies some trade-offs and barriers, and briefly reflects on the impact and future of CSCL@Work.Keywords CSCL, CSCW, distributed cognition, integration of problem framing and problem solving, communities of interest, learning when the answer is not known, meta-design, cultures of participation, social creativity, trade-offs and barriers