1997
DOI: 10.1046/j.1365-4362.1997.00233.x
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Embolia cutis medicamentosa

Abstract: A 35-year-old man presented with a painful skin necrosis after a deep ventrogluteal injection of diclofenac and dexamethasone for treatment of severe back pain. Immediately after the injection, the patient felt a strong pain just above the injection site. In the following days a remarkable necrosis developed in the upper gluteal region. Topical therapy with antiseptics and a topical corticosteroid cream plus analgesia with tramadole revealed no improvement of the symptoms. We excised the necrotic area. Within … Show more

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Cited by 38 publications
(22 citation statements)
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“…It was first described in the 1920s in a patient treated with bismuth salts for syphilis1,2. The phenomenon has been related to the intramuscular administration of a variety of drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and penicillin.…”
Section: Introductionmentioning
confidence: 99%
“…It was first described in the 1920s in a patient treated with bismuth salts for syphilis1,2. The phenomenon has been related to the intramuscular administration of a variety of drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and penicillin.…”
Section: Introductionmentioning
confidence: 99%
“…Nas últimas décadas, foram identificados muitos outros acidentes idênticos, aumentando também o número de casos relatados em publicações médicas e congressos [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] .…”
unclassified
“…3,4 The mechanism may involve direct trauma or arterial embolism caused by drug or compression of an artery after a paravasal injection. 1,4,5 Another hypothesis suggests a vascular pathogenesis (ie, arterial vasospasm may follow penetration of drug microcrystals into a blood vessel). 4 Injection of the offending medication immediately leads to severe pain at the injection site as a result of involvement of peripheral sensory nerves.…”
mentioning
confidence: 99%
“…Necrotic plaques, ulcers, bullae, erosions, and crusts may be observed over the livedoid plaque. 1,2,5 The lesion gradually heals within a few months and an atrophic scar remains at site of injection. 1,2 Although the gluteal region is the most common site for NS, 5 other sites of injection may also be involved.…”
mentioning
confidence: 99%
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