Embolie pulmonaire révélant un syndrome néphrotique : à propos de quatre cas

Chaudesaygues, E.; Grasse, M.; Marchand, Lucien; Villar, Emmanuel; Jf, Aupetit

doi:10.1016/j.ancard.2014.08.010

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…The hypoproteidemia drives most of the clinical consequences of the nephrotic syndrome such as infections, dyslipidemia and thromboses. The thromboses are due to the loss of anti-coagulant proteins such as Antithrombin III (ATIII) [4] and the overproduction of procoagulant factors [5]. So far, no study was conducted in Cote d'Ivoire to assess the biological markers of thrombotic risk in children's INS and the involvement of the c-mip gene in that risk.…”

Section: Discussionmentioning

confidence: 99%

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

N'Draman-Donou,

Yapo,

Koumi-Mélèdje

et al. 2023

Int J Blood Res Disord

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Section: Discussionmentioning

confidence: 99%

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

N'Draman-Donou,

Yapo,

Koumi-Mélèdje

et al. 2023

Int J Blood Res Disord

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“…introduced rivaroxaban in 3 of their patients who presented with VTE associated with NS with good progression [20]. However, no study has evaluated their indication in the context of NS and they are contraindicated in case of creatinine clearance below 30 mL/min.…”

Section: Discussionmentioning

confidence: 99%

Severe Thromboembolic Complication Revealing a Nephrotic Syndrome Due to Segmental and Focal Hyalinosis: A Case Report

Coulibaly¹,

Samaké²,

Fofana³

et al. 2021

OJNeph

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Adult Nephrotic Syndrome (NS) is defined by proteinuria > 3 g/24h or 50 mg/kg/day, hypoprotidemia < 60 g/24h, hypoalbuminemia < 30 g/L. It is a disease with high thromboembolic risk. Peripheral vein thrombosis is common, while its association with pulmonary localizations has been more rarely reported. We report a case of nephrotic syndrome revealed by an association of pulmonary embolism, renal vein and inferior vena cava thrombosis. The diagnosis was confirmed by thoracic angioscan. Renal biopsy revealed Focal Segmental Hyalinosis (FSH). An anti-coagulant treatment and an anti-proteinuric treatment were instituted based on a calcium channel blocker (amlodipine) associated with the conversion enzyme inhibitor (perindopril).

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“…This hypoproteinemia is the basis of most of the clinical consequences of SNI, namely infections due to hypogammaglobulinemia, dyslipidemia but also thrombosis. These thrombosis are the result of an excess of hepatic synthesis with overproduction of pro-coagulant factors such as factors V, VII, VIII, IX (FV, VII, VIII, IX) but also by loss of anti-coagulant proteins such as antithrombin III (ATIII), protein C and protein S [3,4]. Studies have shown that the risk of thrombosis is increased with albuminemia < 20 g/L, fibrinemia > 6 g/L, D-Dimer > 1000 ng/ml or ATIII < 70% in children with SNI [5].…”

Section: Introductionmentioning

confidence: 99%

Thrombotic Risk in Children with Idiopathic Nephrotic Syndrome in Abidjan, Ivory Coast

A. E.,

A. R.

et al. 2023

JABB

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Aims: The objective of this study was to evaluate the thrombotic risk in children of Abidjan suffering with the idiopathic nephrotic syndrome (INS). Study Location and Period: This study was conducted in 56 children with INS, aged 24 to 144 months and followed up at the pediatric nephrology unit of the University Hospital of Yopougon. It took place from January 2021 to April 2022. Blood samples were taken in that unit for each child. Blood counts and albumin levels were performed at the laboratory of biology and medical research of the National Institute of Public Health (INSP) in Adjamé. Fibrinogen, factors V, VII, VIII, IX, antithrombin III (ATIII), protein C, protein S and D-dimers were measured at Laboratory Longchamp of Plateau. Methodology: In each child, blood samples were collected by venipuncture on dry tubes, with sodium citrate and EDTA. Blood counts were performed on Sysmex XT 2000i, albumin levels on Cobas C311 and haemostasis parameters on Sysmex CS1600. Results: Of the 56 children recruited, hypoalbuminemia < 30 g/L was found in 35 (62.5%) children. The most common haemostasis abnormalities were increased D-Dimer in 35 (62.5%) children, hyperfibrinemia in 34(60.7%) children, increased protein C in 31 (55.3%) children, thrombocytosis in 29 (51.8%) children. ATIII and protein S deficiencies were found in 16 (28.6%) and 11 (19.6%) children respectively. Thrombosis risk was present in 36 (64.3%) children. A significant association was found between albuminemia < 20 g/L and ATIII < 70%. Conclusion: There is a thrombotic risk in children with INS, which may be increased by hypoalbuminemia < 20 g/L.

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Embolie pulmonaire révélant un syndrome néphrotique : à propos de quatre cas

Cited by 7 publications

References 11 publications

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

Severe Thromboembolic Complication Revealing a Nephrotic Syndrome Due to Segmental and Focal Hyalinosis: A Case Report

Thrombotic Risk in Children with Idiopathic Nephrotic Syndrome in Abidjan, Ivory Coast

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