Embolization therapy with microspheres for the treatment of liver cancer: State-of-the-art of clinical translation

Pérez-López, Alexandre; Gómez-Lázaro, Laura; Torres-Suárez, Ana Isabel; Aparicio-Blanco, Juan

doi:10.1016/j.actbio.2022.07.019

Cited by 45 publications

(59 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DOX has been emulsified with iodized oil (Lipidol) for transarterial chemoembolization (TACE) since the 1980s ( Ryusaku Yamada et al, 1983 ; Nakamura et al, 1989 ). DOX and other agents have also been loaded into calibrated microspheres for TACE ( Perez-Lopez et al, 2022 ). To evaluate its potential for TACE, GPX350 was prepared with 50 mg mL −1 of DOX (GPX350-DOX50) and 50 mg mL −1 DOX with 30 wt% Ta microparticles (GPX350-DOX50-Ta30).…”

Section: Resultsmentioning

confidence: 99%

Material characterization of GPX®: A versatile in situ solidifying embolic platform technology

Stewart

Sima

Karz³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Endovascular embolization is a minimally invasive procedure during which blood flow to targeted tissues is selectively occluded. The list of clinical indications for embolization continues to expand. Liquid embolic agents are injectable compositions that transition into a solid or semi-solid form when introduced into blood vessels. The mechanism that triggers the liquid-to-solid transition is a key distinguishing feature of liquid embolic agents. GPX is a waterborne liquid embolic agent comprising oppositely charged polyelectrolytes: polyguanidinum and inorganic polyphoshate. In situ solidification is driven by electrostatic condensation of the polyelectrolytes, triggered by ionic strength differentials. We report in vitro characterization of the material properties of GPX, it is in vivo effectiveness in acute animal studies, and its potential for chemoembolization. The viscosity of GPX can be varied over a wide range by adjusting the polyguanidinium MW and/or concentration. Formulation of GPX with either tantalum microparticles (30 wt%) or iodinated radiocontrast agents (300 mgI ml−1) did not significantly change the flow behavior of GPX; the viscosity was independent of shear rate and remained within a clinically practical range (80–160 cP). Formulation of GPX with doxorubicin substantially increased viscosity at low shear rates and resulted in a power law dependence on shear rate. High contrast and effective vascular occlusion were demonstrated in both swine kidneys and rete mirabile. Contrast from iodinated compounds was temporary, dissipating within hours. The doxorubicin in vitro release profile was linear over 90 days. The results demonstrate that GPX is a versatile liquid embolic platform that can be formulated with a wide range of viscosities injectable at clinically practical flow rates, with either transient or permanent contrast, and that can provide prolonged zero-order delivery of doxorubicin to embolized tissues.

show abstract

Section: Resultsmentioning

confidence: 99%

Material characterization of GPX®: A versatile in situ solidifying embolic platform technology

Stewart

Sima

Karz³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…In TAE technology, the choice of embolization material determines the therapeutic effect of interventional embolization [ 163 ]. Drug embolization microspheres not only have a large specific surface area, but also can combine chemotherapy and embolization, which has become a hot spot of current research [ 164 ]. In recent years, a variety of NCTD-loaded embolic microspheres have been developed, and have shown good therapeutic effect in the treatment of liver cancer.…”

Section: Physicochemical Targeted Drug Delivery Systemsmentioning

confidence: 99%

Review targeted drug delivery systems for norcantharidin in cancer therapy

et al. 2022

View full text Add to dashboard Cite

Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has been approved by the State Food and Drug Administration for the treatment of various solid tumors, especially liver cancer. Although NCTD greatly reduces the toxicity of CTD, there is still a certain degree of urinary toxicity and organ toxicity, and the poor solubility, short half-life, fast metabolism, as well as high venous irritation and weak tumor targeting ability limit its widespread application in the clinic. To reduce its toxicity and improve its efficacy, design of targeted drug delivery systems based on biomaterials and nanomaterials is one of the most feasible strategies. Therefore, this review focused on the studies of targeted drug delivery systems combined with NCTD in recent years, including passive and active targeted drug delivery systems, and physicochemical targeted drug delivery systems for improving drug bioavailability and enhancing its efficacy, as well as increasing drug targeting ability and reducing its adverse effects. Graphical Abstract

show abstract

“…Transcatheter arterial embolization (TAE) and transarterial chemoembolization (TACE) refer to the use of a catheter to inject embolic materials into the lesion under the imaging of a contrast agent to block the blood supply to treat tumors. − The success of TAE/TACE mainly depends on the design of the embolic materials. − As a new type of materials for embolization, , microspheres are superior to the conventional embolic materials in terms of efficacy and safety because they are easy to disperse in fluids and flow in microchannels. , Therefore, spherical microspheres are usually taken as the preferred shapes for embolic materials. Depending on the different sizes of the target vessels, embolic microspheres with different sizes have different distribution characteristics and occlusive endpoints. − For easy injection and to reach the distal ends of the blood vessels, the microspheres are desired to have good elasticity. , Moreover, the surface interactions between the microspheres and microchannels also affect their flow behaviors .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Study on Effects of Physico-Chemo-Mechanical Properties of Embolic Microspheres on Embolization Performances

Yang

Deng

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

In this study, the effects of physico-chemical-mechanical properties of embolic microspheres on embolization performances are systematically investigated for the first time in a self-designed and 3D-printed transparent in vitro embolization chip. With droplet microfluidic devices, monodisperse poly(lactic-co-glycolic acid) (PLGA), chitosan, calcium alginate (Ca-ALG), and poly(vinyl alcohol) (PVA) microspheres with uniform shapes and controllable diameters are successfully fabricated. The embolization performances of microspheres with different physico-chemical-mechanical properties, including the elastic properties, surface adhesion properties, and sizes, are evaluated by observing the embolization positions of microspheres in the microchannels inside the chip and measuring the embolization-induced decreases of trans-channel water fluxes of the chip. The results show that for the microspheres with large Young’s moduli and low surface adhesion properties, the microchannel diameters that can be embolized by microspheres are almost the same as the corresponding microsphere diameters; however, when the microspheres have very low Young’s moduli, they can deform in the microchannels and pass through microchannels with diameters much smaller than the microsphere diameters. Generally, embolic microspheres with good elastic property, low surface adhesion property, and suitable size can achieve desired embolization performances. This work provides a new platform for controllable fabrication and performance characterization of future materials for embolization, and the results provide valuable guidance for designing efficient embolic materials for the transcatheter arterial embolization therapy.

show abstract

Embolization therapy with microspheres for the treatment of liver cancer: State-of-the-art of clinical translation

Cited by 45 publications

References 142 publications

Material characterization of GPX®: A versatile in situ solidifying embolic platform technology

Material characterization of GPX®: A versatile in situ solidifying embolic platform technology

Review targeted drug delivery systems for norcantharidin in cancer therapy

In Vitro Study on Effects of Physico-Chemo-Mechanical Properties of Embolic Microspheres on Embolization Performances

Contact Info

Product

Resources

About