Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis

Hauer, Bernhard

doi:10.1021/acscatal.0c01708

Cited by 225 publications

(169 citation statements)

References 106 publications

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“…Still, not every new biocatalytic reaction (theoretically) possible or working on small scale makes it into an industrial process for various reasons, as also pointed out by Hauer very recently [11] . Many of these reasons also apply to new chemical reactions, which never make it into production.…”

Section: Introductionmentioning

confidence: 99%

Biocatalysis: Enzymatic Synthesis for Industrial Applications

et al. 2020

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in 2007, followed by postdoctoral studies at York University (UK) and Greifswald University (Germany). In 2010, she transitionedto industry applying and developing biocatalytic technologies at Novacta in the UK, prior to joining Chemical Process Development at GSK, with responsibility for the development and implementation of new biocatalytic technologyi nboth pre-and post-commercialization routes. Since Dec. 2016, Radka is leading the Bioreactions group in GDC at the Novartis Institute for Biomedical Research in Basel, Switzerland. Jeffrey Moore obtained his PhD in Chemical Engineeringf rom the California Institute of Technology in 1996 as Frances Arnold's first Directed Evolution graduate student. His foundational work led to an evolved p-nitrobenzyl esterase and the Lonza Centenary Prize (1997). In 1996, he joined the Biocatalysis Group of Merck & Co.in Rahway NJ, spending two decades inventing new enzymes and new enzymatic processes. In 2018, he transitionedtothe Merck Protein EngineeringG roup responsible for evolving enzymes for the discovery,d evelopmenta nd commercials cale manufacture of medicines. He has been awarded aUS Presidential Green Chemistry Award (2010), the BioCat2012 Award (2012) and the Thomas Edison Inventorship Award (2014). Kai Baldenius studied chemistry in Hamburg and Southampton. He received his PhD for research in asymmetric organometallic catalysis, supervised by H. tom Dieck and H. B. Kagan. After his postdoc on natural product synthesis with K. C. Nicolaou at the Scripps Research Institute he joined BASF in 1993. Kai served BASF in various functions (R&D, production, marketing, sales) before he took the lead of BASF'sbiocatalysis research for almost ad efcade. He left BASF to become afree-lancing consultanti n2019 and in 2020 he has founded Baldenius Biotech Consulting. Uwe T. Bornscheuer studied chemistry and received his PhD in 1993 at Hannover University followed by apostdoc at Nagoya University (Japan). In 1998, he completed his Habilitation at Stuttgart University about the use of lipases and esterasesi n organic synthesis. He has been Professor at the Institute of Biochemistry at Greifswald University since 1999. Beside other awards, he received in 2008 the BioCat2008 Award. He was just recognized as "Chemistry Europe Fellow". His current research interest focuses on the discovery and engineering of enzymes from various classes for applications in organic synthesis, lipid modification, degradation of plastics or complex marine polysaccharides.

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Section: Introductionmentioning

confidence: 99%

Biocatalysis: Enzymatic Synthesis for Industrial Applications

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“…Additionally, a significant investment of both time and money is necessary to develop a biocatalytic process. This is especially true for synthetic biology, e. g. in the case of the anti‐malarial drug artemisinin which required 10 years of research and >$150 million to engineer an organism that could produce it [155] . Clearly, additional research to address these issues is needed and a closer interaction between academia and industry could further speed up the process.…”

Section: Discussionmentioning

confidence: 99%

“…in the case of the anti-malarial drug artemisinin which required 10 years of research and >$150 million to engineer an organism that could produce it. [155] Clearly, additional research to address these issues is needed and a closer interaction between academia and industry could further speed up the process. Nonetheless, the many examples of successful biocatalytic processes mentioned in this review (as well as many not mentioned) highlight the power of enzymes and the bright future of the field of biocatalysis.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Looking Back: A Short History of the Discovery of Enzymes and How They Became Powerful Chemical Tools

Heckmann

Paradisi

2020

ChemCatChem

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Enzymatic approaches to challenges in chemical synthesis are increasingly popular and very attractive to industry given their green nature and high efficiency compared to traditional methods. In this historical review we highlight the developments across several fields that were necessary to create the modern field of biocatalysis, with enzyme engineering and directed evolution at its core. We exemplify the modular, incremental, and highly unpredictable nature of scientific discovery, driven by curiosity, and showcase the resulting examples of cutting-edge enzymatic applications in industry.

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“…[3b] Tr otzdem schafft es nicht jede neue biokatalytische Reaktion, die (theoretisch) mçglich ist oder im kleinen Maßstab funktioniert, aus verschiedenen Gründen in ein industrielles Verfahren, wie kürzlich in einem Review von Hauer festgestellt wurde. [11] Viele dieser Gründe gelten auch fürn eue chemische Reaktionen, die oft nicht in den Produktionsmaßstab umgesetzt werden. Beispielsweise kann es schwierig sein, ein neues Verfahren zu implementieren, einfach weil dies neue Investitionen in eine Fabrikanlage erfordert, während ein alter Prozess in einer abgeschriebenen Anlage noch profitabel läuft.…”

Section: Introductionunclassified

“…Trotzdem schafft es nicht jede neue biokatalytische Reaktion, die (theoretisch) möglich ist oder im kleinen Maßstab funktioniert, aus verschiedenen Gründen in ein industrielles Verfahren, wie kürzlich in einem Review von Hauer festgestellt wurde [11] . Viele dieser Gründe gelten auch für neue chemische Reaktionen, die oft nicht in den Produktionsmaßstab umgesetzt werden.…”

Section: Introductionunclassified

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

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www.angewandte.de 2020 Die Autoren. Verçffentlicht von Wiley-VCH GmbH. Dieser Open Access Beitrag steht unter den Bedingungend er Creative Commons AttributionN on-CommercialN oDerivs License, die eine Nutzung und Verbreitung in allen Medien gestattet, sofern der ursprüngliche Beitrag ordnungsgemäßzitiert und nicht fürkommerzielle Zwecke genutzt wird und keine ¾nderungen und Anpassungen vorgenommen werden.

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Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis

Cited by 225 publications

References 106 publications

Biocatalysis: Enzymatic Synthesis for Industrial Applications

Biocatalysis: Enzymatic Synthesis for Industrial Applications

Looking Back: A Short History of the Discovery of Enzymes and How They Became Powerful Chemical Tools

Biokatalyse: Enzymatische Synthese für industrielle Anwendungen

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