Embryo developmental stage at transfer influences outcome of treatment with intracytoplasmic sperm injection

Zhu, Jianjun; Meniru, Godwin I.; Craft, Ian

doi:10.1007/bf02765824

Cited by 13 publications

(4 citation statements)

References 13 publications

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“…Despite the similar fertilization rates in all ICSI groups, a highly significant decrease in embryo quality in patients with repeated cycles was observed, whereas the embryo score was similar in patients with successive cycles in conventional IVF. This is in accordance with the pregnancy results reported by Zhu et al (1997). The causes of the differences between ICSI and conventional IVF are unclear.…”

Section: Discussionsupporting

confidence: 92%

Different cumulative pregnancy rates in patients with repeated IVF- or ICSI cycles: possible influence of a male factor

Stalf¹,

Herrero²,

Turley³

et al. 1999

Andrologia

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The low rate of ongoing pregnancies in IVF cycles leads to a high number of repeated cycles in couples with previously failed attempts. Therefore it would be helpful to have a prediction about the chance of becoming pregnant in a repeated cycle. In a retrospective study the data of about 4246 cycles were analysed. Because the pregnancy rates in IVF- and ICSI cycles are generally different, these two groups were distinguished between and the outcome in patients with one, two or more attempts was analysed. The rate of ongoing pregnancies per patient was lower after IVF (24.9%) than after ICSI (32.9%), but was similar or even slightly increased in patients with more than one attempt. On the other hand, there was a high pregnancy rate with ICSI in the first two cycles (35.9%), but patients with more than two ICSI cycles had a significantly lower chance of becoming pregnant (20.7%). Factors that are known to influence the pregnancy rate, such as stimulation protocol, oocyte quality or number of transferred embryos, were similar in all groups. However, significantly reduced embryo quality with successive cycles was only observed in ICSI patients. There might be a negative selection of patients with poor embryo quality and previously failed attempts after ICSI, possibly due to an andrological factor. The differences between IVF- and ICSI patients are based on treatment indications, and andrological diseases are the predominant indication for ICSI. Although no correlation was found between changes in conventional sperm parameters and number of treated cycles, there might be a subgroup of andrological patients selected by repeatedly failed ICSI cycles. Chromosomal or genetic disturbances in spermatozoa of this subgroup could be the reason for failure.

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Section: Discussionsupporting

confidence: 92%

Different cumulative pregnancy rates in patients with repeated IVF- or ICSI cycles: possible influence of a male factor

Stalf¹,

Herrero²,

Turley³

et al. 1999

Andrologia

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“…This awareness of the higher pregnancy chance offered by transferring good quality embryos led to the reduction of the number of transferred embryos to two and consequently to the avoidance of triplet pregnancies (Staessen et al, 1992(Staessen et al, , 1995. Still the concept of quality was predominantly based on the results of transfers with a mixture of embryos of different types (Zhu et al, 1997;Hu et al, 1998). Only Ziebe (Ziebe et al, 1997), who considered exclusively transfers of identical cleavage stage and identical fragmentation, and 2347…”

Section: Discussionmentioning

confidence: 99%

Characterization of a top quality embryo, a step towards single-embryo transfer

et al. 1999

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In most in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programmes approximately one ongoing pregnancy in three is multiple. The need to characterize embryos with optimal implantation potential is obvious. We retrospectively examined all of 23 double transfers resulting in ongoing twins, occurring between January 1, 1996 and May 19, 1997. Characteristics of these top quality embryos were absence of multinucleated blastomeres, four or five blastomeres on day 2, seven or more cells on day 3, and 2 embryos, 11/31 (35%) were multiple. We applied our top quality criteria to the 221 double transfers: 106 transfers with two top embryos resulted in 65 (63%) ongoing pregnancies with 37 (57%) twins, 65 transfers with one top embryo in 38 (58%) ongoing pregnancies with eight (21%) twins. In the group without top embryos, 12/52 (23%) ongoing singletons occurred, with no twins. The corresponding ongoing implantation rates were 49, 35 and 12%. This analysis suggests that single embryo transfer with an acceptable pregnancy rate might be considered if a top quality embryo is available.

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“…The number of morphologically normal cells is the most used and valid method of selection of embryos of high implantation potential (24)(25)(26), pregnancy, and birth (27) and even of neonate weight (28). Slow-growing embryos have a markedly impaired capacity to implant (29,30). Faster-cleaving embryos lead to more morulae and blastocysts and to a higher proportion of viable fetuses (31,32).…”

Section: Importance Of Early Embryo Developmentmentioning

confidence: 99%

Sildenafil citrate (Viagra) impairs fertilization and early embryo development in mice

Glenn¹,

McClure²,

Cosby

et al. 2009

Fertility and Sterility

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Embryo developmental stage at transfer influences outcome of treatment with intracytoplasmic sperm injection

Cited by 13 publications

References 13 publications

Different cumulative pregnancy rates in patients with repeated IVF- or ICSI cycles: possible influence of a male factor

Different cumulative pregnancy rates in patients with repeated IVF- or ICSI cycles: possible influence of a male factor

Characterization of a top quality embryo, a step towards single-embryo transfer

Sildenafil citrate (Viagra) impairs fertilization and early embryo development in mice

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