Embryo Form Project: An original technique for the three-dimensional reconstruction of human embryo morphology

Labrousse, M.; Micard, Émilien; Tonnelet, Romain; Cendre, Romain; Delmas, V.; Naidich, T.; Braun, Marc

doi:10.1016/j.reprotox.2015.07.076

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…5,6 Despite computer assistance, these approaches remained tedious to design, gave uneven results, and are destructive to fetuses. 7,8 To explore fetal death, post-mortem (PM) examination, also called fetopathologic examination, is the gold standard for an accurate diagnosis and aims to allow for genetic counseling and to specify the recurrence risk. 9 PM examination consists of a fetal and placental examination and includes standard radiographs; photographs; external morphology examination with biometric data such as weight, size, cranial perimeter, and foot length; and internal examination (i.e., autopsy).…”

Section: Introductionmentioning

confidence: 99%

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Micro‐CT and high‐field MRI for studying very early post‐mortem human fetal anatomy at 8 weeks of gestation

Lamouroux,

Cardoso,

Bottero

et al. 2023

Prenatal Diagnosis

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ObjectiveThis study involved very early post‐mortem (PM) examination of human fetal anatomy at 8 weeks of gestation (WG) using whole‐body multimodal micro‐imaging: micro‐CT and high‐field MRI (HF‐MRI). We discuss the potential place of this imaging in early first‐trimester virtual autopsy.MethodsWe performed micro‐CT after different contrast‐bath protocols including diffusible iodine‐based contrast‐enhanced (dice) and HF‐MRI with a 9.4 T machine with qualitative and quantitative evaluation and obtained histological sections.ResultsNine fetuses were included: the crown–rump length was 10–24 mm and corresponded to 7 and 9 WG according to the Robinson formula. The Carnegie stages were 17–21. Dice micro‐CT and HF‐MRI presented high signal to noise ratio, >5, according to the Rose criterion, and for allowed anatomical phenotyping in these specimens. Imaging did not alter the histology, allowing immunostaining and pathological examination.ConclusionPM non‐destructive whole‐body multimodal micro‐imaging: dice micro‐CT and HF‐MRI allows for PM human fetal anatomy study as early as 8 WG. It paves the way to virtual autopsy in the very early first trimester. Obtaining a precision phenotype, even regarding miscarriage products, allows a reverse phenotyping to select variants of interest in genome‐wide analysis, offering potential genetic counseling for bereaved parents.

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Section: Introductionmentioning

confidence: 99%

“…A 3D atlas was published for practical implementation, and De Bakker's team made the atlas available to the scientific community in a dedicated website around 2015 5,6 . Despite computer assistance, these approaches remained tedious to design, gave uneven results, and are destructive to fetuses 7,8 …”

Section: Introductionmentioning

confidence: 99%