Embryo implantation after assisted reproductive procedures and maternal thrombophilia

Martinelli, Ida; Passamonti, Serena Maria; Battaglioli, Tullia; Taioli, Emanuela; Ragni, G.; Levi-Setti, Paolo Emanuele; Lodigiani, Corrado; Mannucci, P. M.

doi:10.1111/j.1538-7836.2003.tb03490.x

Cited by 44 publications

(65 citation statements)

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“…This stand referred to another discussion concerning the significance of paternal [71] and fetal thrombophilia for early pregnancy development [72]. Similar results show Martinelli et al [58] reporting 86% pregnancy rate after first IVF attempt in FVL and FII 20210 G>A carriers compared to 68% pregnancy rate in non-carriers (non-significant difference). Although not all authors [72] share the proposition, FVL could improve implantation rate in IVF and spontaneous cycles.…”

Section: Advantages and Disadvantages Of Fvl During Implantationsupporting

confidence: 76%

“…After this report, series of consequent papers discussed the influence of thrombophilia on implantation process, especially after IVF procedure. Some studies found [23,24] but others not [58,69] a relation of FVL and FII 20210 G>A with implantation failure. The conflicting results show the necessity of large and specific inclusion criteria fulfilling studies to detect the real connection between the presence of increased thrombin generating factors and implantation outcomes.…”

Section: Advantages and Disadvantages Of Fvl During Implantationmentioning

confidence: 99%

“…They established this polymorphism as the most common SNP among women with IVF implantation failure. Before that Martinelli et al [58] found 19% prevalence of TT genotype evaluating 162 women with failed IVF/ICSI treatment. Moreover, Azem et al [59] who investigated 45 women with a history of four or more failed IVF cycles reported an incidence of 17.8%.…”

Section: Mthfr Polymorphisms and Embryo Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Ivanov¹,

Tomov²,

Tsvyatkovska³

et al. 2013

Pregnancy Thrombophilia - The Unsuspected Risk

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Section: Advantages and Disadvantages Of Fvl During Implantationsupporting

confidence: 76%

Section: Advantages and Disadvantages Of Fvl During Implantationmentioning

confidence: 99%

Section: Mthfr Polymorphisms and Embryo Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Ivanov¹,

Tomov²,

Tsvyatkovska³

et al. 2013

Pregnancy Thrombophilia - The Unsuspected Risk

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“…In their study, Martinelli et al compared the prevalence of thrombophilia in infertile patients with an IVF cycle failure (n = 234) with that in a control group of patients that impregnated spontaneously (n = 234) 15 . The heterozygous form of the factor V (Leiden) mutation was present in 5 % patients of the study group compared to 2 % patients of the control group.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Machac¹,

Ľubušký²,

Procházka³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background and objective:To determine the prevalence of markers of inherited thrombophilia in patients with severe form of ovarian hyperstimulation syndrome (OHSS) Design and methods: Blood samples were analysed for markers of thrombophilia (mutation of factor V -Leiden, mutation of methylentetrahydrofolat reductase (MTHFR) C677T and mutation of prothrombin G20210A). The study group consisted of women who had undergone controlled ovarian hyperstimulation for IVF complicated by severe OHSS (group A, n = 50). Results were compared with two controls groups -women who underwent ovarian hyperstimulation for IVF without developing OHSS (group B, n = 93) and healthy pregnant women with no history of infertility (group C, n = 196).Results: We have found 7 out of 50 patients from group A positive for Leiden mutation (heterozygous) 11 out of 93 from group B (heterozygous), p = 0.71 OR 1.21 (0.39 3.70) and 10 out of 196 from group C (heterozygous), p = 0.03 OR 3.03 (0.97 9.28). Polymorphism of MTHFR 677T gene was detected in 17 out of 50 patients (heterozygous) from group A, in 36 out of 93 patients from group B (35 heterozygous, 1 homozygous) and in 93 out of 196 patients from the group C (86 heterozygous, 7 homozygous) with no statistical significance. Conclusions:We found an increased prevalence of factor V Leiden mutation in Czech infertile women. However carriers of Leiden mutation had no enhanced risk of development severe form of OHSS during stimulation.

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“…Conversely, multiple studies also exist that refute the idea of inherited thrombophilias affecting IVF outcomes [9][10][11]. These three studies examined the effects of the following inherited thrombophilias: factor V Leiden, prothrombin G20210A, and MTHFR.…”

Section: Introductionmentioning

confidence: 99%

Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients

Patounakis

Bergh

Forman

et al. 2015

J Assist Reprod Genet

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Purpose The aim of the study is to determine if thrombophilic single nucleotide polymorphisms (SNPs) affect outcomes in fresh in vitro fertilization (IVF) cycles in a large general infertility population. Methods A prospective cohort analysis was performed at a university-affiliated private IVF center of female patients undergoing fresh non-donor IVF cycles. The effect of the following thrombophilic SNPs on IVF outcomes were explored: factor V (Leiden and H1299R), prothrombin (G20210A), factor XIII (V34L), β-fibrinogen (-455G→A), plasminogen activator inhibitor-1 (4G/5G), human platelet antigen-1 (a/b9L33P), and methylenetetrahydrofolate reductase (C677T and A1298C). The main outcome measures included positive pregnancy test, clinical pregnancy, embryo implantation, live birth, and pregnancy loss. Results Patients (1717) were enrolled in the study, and a total of 4169 embryos were transferred. There were no statistically significant differences in positive pregnancy test, clinical pregnancy, embryo implantation, live birth, or pregnancy loss in the analysis of 1717 patients attempting their first cycle of IVF. Receiver operator characteristics and logistic regression analyses showed that outcomes cannot be predicted by the cumulative number of thrombophilic mutations present in the patient. Conclusions Individual and cumulative thrombophilic SNPs do not affect IVF outcomes. Therefore, initial screening for these SNPs is not indicated.

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Embryo implantation after assisted reproductive procedures and maternal thrombophilia

Cited by 44 publications

References 0 publications

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Thrombophilia in Assisted Reproductive Technology — Place and Needs of Thromboprophylaxis

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients

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