Embryo outcome in Y‐chromosome microdeleted infertile males after ICSI

Kihaile, Paul E.; Kisanga, Ramzy E.; Aoki, Katsumi; Kumasako, Yoko; Misumi, Junichi; Utsunomiya, Takafumi

doi:10.1002/mrd.20074

Cited by 25 publications

(24 citation statements)

References 54 publications

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“…Our study showed no significant differences in embryo implantation, biochemical pregnancy, clinical pregnancy, ectopic pregnancy, delivery, early miscarriage, late miscarriage and ratio of male/female babies in men with or without microdeletion, suggesting that Y chromosome AZFc microdeletion does not affect the outcomes of ICSI treatment. The studies of Patrat et al [33], Kihaile et al [10] and Choi et al [4] have shown similar results. Bellver [34] indicated that Y chromosome AZFc microdeletions do not seem to be related to recurrent spontaneous abortion (RSA) of unknown origin.…”

Section: Discussionmentioning

confidence: 53%

“…However, this differs with the report by Oates et al [27] who concluded that sperm production appeared stable over time. Table 6 shows that a have few studies precisely analyzed how Y chromosome microdeletion influences fertilization rate, embryo quality, and pregnancy rates [9,10,12,26,27,33]. Our study showed no significant differences in embryo implantation, biochemical pregnancy, clinical pregnancy, ectopic pregnancy, delivery, early miscarriage, late miscarriage and ratio of male/female babies in men with or without microdeletion, suggesting that Y chromosome AZFc microdeletion does not affect the outcomes of ICSI treatment.…”

Section: Discussionmentioning

confidence: 56%

“…Our results confirmed the results of previous studies [24,25] in a larger cohort. Recently, several investigators have shown that embryo characteristics following ICSI using sperm obtained from men with Y chromosome microdeletions were not adversely affected by the deletion [4,9,10,26,27]. ICSI brings new hope for severe oligozoospermic men who wish to conceive children with their own gametes [28].…”

Section: Discussionmentioning

confidence: 99%

“…1). The AZF deletions are known to be associated with various spermatogenetic alterations including Sertoli cell-only syndrome (SCOS), maturation arrest, and hypospermatogenesis [9,10]. The development of intracytoplasmic sperm injection (ICSI) has allowed patients with severe oligozoospermia to have children.…”

Section: Introductionmentioning

confidence: 99%

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Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Liu

Qiao

et al. 2013

J Assist Reprod Genet

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Purpose To explore whether the presence of a Y chromosome AZFc microdeletion confers any adverse effect on the outcomes of intracytoplasmic sperm injection (ICSI) with fresh ejaculated sperm. Methods A total of 143 oligozoospermia patients with Y chromosome AZFc microdeletion in ICSI cycles in a fiveyear period were studied. Infertile men with normal Y chromosome in ICSI at the same time-frame were used as controls matched to the study group for age of female, female's body mass index, male's age, infertility duration and number of oocytes retrieved. Retrospective case-control study was used. Results There were no significant differences between groups in clinical outcomes of endometrial thickness, transferred embryos, good embryo rates, implantation rates, biochemical pregnancy rates, clinical pregnancy rates, ectopic pregnancy rates, miscarriage rates, preterm birth rates, the ratio of male and female babies, newborn body height, newborn weight, low birth weight and birth defects (P>0.05). Patients with Y chromosome AZFc microdeletion had a lower fertilization rate (61.8 % vs. 67.8 %, P<0.05) and higher cleaved embryo rate (94.0 % vs. 88.1 %, P<0.05). Conclusions ICSI clinical outcomes for oligozoospermic patients with Y chromosome AZFc microdeletion are basically comparable to that of infertile patients with normal Y chromosomes. The results of ICSI were not affected by the AZFc deletion. Preimplantation genetic diagnosis (PGD) before ICSI for Y chromosome AZFc microdeletion may not be a justifiable regular procedure if the couples didn't care the vertical transmission of Y chromosome deletion.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Liu

Qiao

et al. 2013

J Assist Reprod Genet

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“…Moreover, about 10% to 15% of idiopathic cases of azoospermia and severe oligozoospermia have microdeletions in AZF regions as the etiologic factor [12][13][14]. The frequency of Y chromosome microdeletions varies between 1% [15] and 55% [16] in the worldwide whereas the few studies performed in Asian male populations showed frequencies of 7.6% to 16.5% in Japan [17][18][19][20][21][22], 11.0% to 19.4% in China [23,24], 10.6% to 11.7% in Taiwan [25,26], 6.4% in Hong Kong [27] and 2.0% to 12.0% in India [12,28,29]. A recently published study reported that the cumulative frequency of Y chromosome microdeletions was 3.5 % in infertile males [30].…”

Section: Abstract Y Chromosome Microdeletion Chromosomal Abnormalitmentioning

confidence: 99%

Molecular and cytogenetic studies of 101 infertile men with microdeletions of Y chromosome in 1,306 infertile Korean men

Kim

Choi

Park

et al. 2012

J Assist Reprod Genet

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Objectives To determine the prevalence of Y chromosome microdeletions in infertile Korean men with abnormal sperm counts and to assess the clinical features and frequency of chromosomal abnormalities in Korean patients with microdeletions. Methods A total of 1,306 infertile men were screened for Y chromosome microdeletions, and 101 of them had microdeletions. These 101 men were then retrospectively studied for cytogenetic evaluation, testicular biopsy and outcomes of IVF and ICSI. ResultsThe overall prevalence of Y chromosome microdeletions in infertile men was 7.7 % (101/1,306). Most microdeletions were in the AZFc region (87.1%), including deletions of AZFbc (24.7 %) and AZFabc (8.9 %). All patients with AZFa, AZFbc and AZFabc deletions had azoospermia, whereas patients with an AZFc deletion usually had low levels of sperm in the ejaculate or in the testis tissues. Chromosomal studies were performed in 99 men with microdeletions, 36 (36.4%) of whom had chromosomal abnormalities. Among the infertile men with Y chromosome microdeletions in this study, the incidence of chromosomal abnormality was 48.6% in the azoospermic group and 3.7% in the oligozoospermic group. Among the 69 patients with microdeletions and available histological results, 100.0% of the azoospermic group and 85.7% of the oligozoospermic group had histological abnormalities. The frequency of both chromosomal abnormalities and histological abnormalities was higher in the azoospermic group compared to the oligozoospermic group. Thirtyfour ICSI cycles with either testicular (n014) or ejaculated spermatozoa (n020) were performed in 23 couples with men with AZFc microdeletion. Thirteen clinical pregnancies (39.4%) were obtained, leading to the birth of 13 babies. Conclusions The study results revealed a close relationship between microdeletions and spermatogenesis, although IVF outcome was not significantly affected by the presence of the AZFc microdeletion. Nevertheless, Y chromosome microdeletions have the potential risk of being transmitted from infertile fathers to their offspring by ICSI. Therefore, before using ICSI in infertile patients with severe spermatogenic defects, careful evaluations of chromosomal abnormalities and Y chromosome microdeletions screening should be performed and genetic counseling should be provided before IVF-ET.Capsule A close relationship exists between microdeletions and spermatogenesis, although IVF outcome was not significantly affected by the presence of an AZFc microdeletion.

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Current awareness in prenatal diagnosis

2004

Prenatal Diagnosis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of prenatal diagnosis. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General Interest; 3 Normal Fetal Development; 4 Gametogenesis and Pre‐implantation Diagnosis; 5 First Trimester Diagnosis; 6 Second Trimester Diagnosis; 7 Fetal Diagnosis by Ultrasound and Other Imaging; 8 Maternal Screening; 9 Screening for Carriers of Genetic Abnormality; 10 Technological Developments; 11 Confined Placental Mosaicism and Uniparental Disomy; 12 Molecular Cytogenetics; 13 Fetal Cells in Maternal Circulation; 14 Fetal Therapy; 15 Psychosocial Aspects; 16 Epidemiology and Environmental Factors; 17 Developmental Pathology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Embryo outcome in Y‐chromosome microdeleted infertile males after ICSI

Abstract: in Y-chromosome microdeletion cycles in which sperm cells were available for intracytoplasmic sperm injection (ICSI), embryo outcome was comparable to conventional IVF.

Cited by 25 publications

References 54 publications

Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Y chromosome AZFc microdeletion may not affect the outcomes of ICSI for infertile males with fresh ejaculated sperm

Molecular and cytogenetic studies of 101 infertile men with microdeletions of Y chromosome in 1,306 infertile Korean men

Current awareness in prenatal diagnosis

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