Embryo transfer as a means of controlling the transmission of viral infections. I. The exposure of preimplantation bovine embryos to akabane, bluetongue and bovine viral diarrhea viruses

Singh, Elizabeth L.; Eaglesome, M.D.; Thomas, F C; Papp-Vid, G; Hare, W.C.D.

doi:10.1016/0093-691x(82)90025-5

Cited by 79 publications

(10 citation statements)

References 7 publications

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“…They provide further evidence that the properties ofthe zona pellucida of the in vitro-produced embryo are different from those of the in vivo embryo in terms of potential BVDV transmission (Singh andothers 1982, Bielanski andHare 1988). Whether BVDV can fully penetrate the zona (as suggested by Brownlie and others 1997) or whether it merely adheres to the zona of in vitro-produced embryos (Vanroose and others 1998) is still undear.…”

Section: Histopathologymentioning

confidence: 90%

Bovine abortion associated withNeospora caninumin northern Spain

et al. 1999

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During 1996, aborted bovine fetuses from dairy herds in norther Spain were examined by histopathological, immunohistochemical and serological methods for evidence of infection by Neospora caninum. Microscopical brain changes consistent with those of neosporosis were detected in 36 of 81 fetuses and specific antibodies (IFAT titres > or = 1/16) in 32 of 63. Eight fetuses with neurological lesions were seronegative, and eight without lesions were seropositive. In 25 of 34 fetal brains with lesions consistent with published descriptions of neosporosis, immunohistochemical analysis revealed the presence of N caninum antigen. Depending on the diagnostic criteria, the prevalence of neosporosis related to bovine abortion was between 32 and 57 per cent of the fetuses submitted and between 33 and 58 per cent of the herds involved. Data on the geographical, seasonal and fetal age distribution of the infection are given for the fetuses examined and the value of the different diagnostic methods is discussed.

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Section: Histopathologymentioning

confidence: 90%

Bovine abortion associated withNeospora caninumin northern Spain

et al. 1999

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“…The BVDV indicated that embryos produced using in vitro maturation and IVF from infected cattle (whose FF and cumulus-oocyte complexes were positive for virus) remained negative for the virus after at least 7 days (34). There are many more studies where bovine embryos were exposed to several types of viruses (acabane virus, bovine leukemia virus, bluetongue virus, BVDV, and foot-and-mouth disease virus) and the pathogen was not detected on the embryo (22,23,(35)(36)(37)(38). In another study, Van Soom et al (39) reported isolation of BVDV from FF of donors selected for IVF and in culture media used for production of IVF embryos.…”

Section: Embryosmentioning

confidence: 94%

“…Whatever the reason, these studies indicate that the risk for disease transmission from embryos is quite low. It should also be pointed out that the ART techniques (i.e., IVF, intracytoplasmic sperm injection [ICSI], embryo transfer) suspected of being at risk for disease transmission are actually used as tools in the livestock industry to reduce disease transmission in diseased animals because of the ability to produce pathogen-free oocytes, embryos, and sperm (22,23).…”

Section: Risks Of Cross-contaminationmentioning

confidence: 99%

Storage of cryopreserved reproductive tissues: evidence that cross-contamination of infectious agents is a negligible risk

Pomeroy

Harris

Conaghan

et al. 2010

Fertility and Sterility

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“…The results show that the zona pellucida protects the early embryo from SFV and RV infection. Prevention of virus entry by the zona pellucida is not unique to SFV infection; bovine viral diarrhoea and Akabane viruses (Singh et al, 1982), bluetongue virus (Bower et al, 1982) and Newcastle disease virus (Glass et al, 1974) are also unable to penetrate the zona. However, other viruses can readily cross the zona pellucida, for example Mengo encephalitis virus (Gwatkin, 1963(Gwatkin, , 1967, western equine encephalomyelitis virus (Gwatkin, 1971) and coxsackie B3 virus (Eaglesome et al, 1980).…”

Section: Infection Of Isolated Icm Cellsmentioning

confidence: 99%

Infection of Cultured Early Mouse Embryos with Semliki Forest and Rubella Viruses

1986

Journal of General Virology

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SUMMARYEarly mouse embryos at the four-to eight-cell stage or the blastocyst stage could be infected with the A7 strain of Semliki Forest virus (SFV) after the removal of the zona pellucida, either by Pronase treatment or following hatching of blastocysts. With SFV, rapid virus production and eventual cytolysis resulted from infection at either stage. For four-to eight-cell embryos the cytopathic effect was delayed and a proportion of embryos developed to the blastocyst stage. Four-and eight-cell embryos could not be infected with rubella virus (RV), even after removal of the zona pellucida. RV infection of zona-free blastocysts resulted in a productive but non-cytolytic infection which did not affect embryonic development to the early egg-cylinder stage. RV did not multiply in inner cell mass cells isolated from embryos at the blastocyst stage, although SFV did multiply in such cells.

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Embryo transfer as a means of controlling the transmission of viral infections. I. The exposure of preimplantation bovine embryos to akabane, bluetongue and bovine viral diarrhea viruses

Cited by 79 publications

References 7 publications

Bovine abortion associated withNeospora caninumin northern Spain

Bovine abortion associated withNeospora caninumin northern Spain

Storage of cryopreserved reproductive tissues: evidence that cross-contamination of infectious agents is a negligible risk

Infection of Cultured Early Mouse Embryos with Semliki Forest and Rubella Viruses

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