Embryo-uterine interactions during early stages of pregnancy in domestic mammals

Guillomot, Michel; Reinaud, Pierrette; Charpigny, Gilles; Martal, J.

doi:10.1051/rnd:19881008

Cited by 10 publications

(13 citation statements)

References 44 publications

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“…uteroferrin (Dantzer and Nielsen 1984;Raub et al 1985) and probably hormones (Stice et al 1987). For reviews see Dantzer (1986) and Guillomot et al (1988). It has been suggested that these substances may act as a mechanism for signal transmitter substances (compare Reynolds et al 1985) due to the specialized areolar venous systems.…”

Section: Vasculature-based Characteristics Of the Regular And Irregulmentioning

confidence: 99%

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Microvasculature of regular and irregular areolae of the areola-gland subunit of the porcine placenta: structural and functional aspects

Dantzer¹,

Leiser

1993

Anat Embryol

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To examine the vasculature of the areola-gland subunit of advanced pig placenta, tissues from ten animals between 43 and 112 days of gestation were prepared for histology and for scanning electron microscopy of vascular corrosion casts from both maternal and fetal sides. Regular areolae, tributary to one gland only, are round with a wide-meshed and smooth subepithelial capillary network on the maternal side, which is similar to the pre-implantative stage and bordered by an abrupt rim towards the inter-areolar maternal capillary network. On the fetal side, the capillary network follows papillae which protrude into the areolar cavity or converge to form a ring towards the areolar periphery. Irregular areolae, in contrast, have indistinct boundaries and are characterized by two or more gland openings. The maternal capillary network has moderate density and follows the corrugations, whereas the fetal capillary network is basically two-dimensional with some blunt sinusoidal protrusions. Vessel architecture of both areolar types implies facilitated external inflow of blood into the areola on arteriolar as well as on capillary levels, whereas the outflow from the areolar capillaries comprises venules converging into one or two areolar stem veins, and therefore conducts venous blood in a manner different from that of the inter-areolar region. It is suggested that this arrangement could favour vascular control mechanisms in uterus, placenta and fetus. On the basis of these observations and the discussion, it is suggested that these areola-specific vessel systems are important for sustaining the characteristic substance transfers in the areola, the secretion, metabolism and absorption, which according to the literature are not the same in the regular as in the irregular areolar type of the porcine areola-gland subunit of the placenta.

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Section: Vasculature-based Characteristics Of the Regular And Irregulmentioning

confidence: 99%

“…The columnar to cuboidal epithelium of the uterine glands is implicated among other functions in the synthesis of the placental iron-carrier protein, uteroferrin (Wislocki and Dempsey 1946;Bazer 1975;Chen et al 1975;Dantzer and Nielsen 1984;Raub et al 1985 ;Firth et al 1986a;Guillomot et al 1988). …”

Section: Introductionmentioning

confidence: 99%

Microvasculature of regular and irregular areolae of the areola-gland subunit of the porcine placenta: structural and functional aspects

Dantzer¹,

Leiser

1993

Anat Embryol

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“…This protein is produced by the extra embryonic trophectoderm since transfer of trophoblastic vesicles block the cyclic luteolysis of the recipient females [15] and has been located in the trophoblastic cells by immunohistochemistry [9]. Ovine trophoblastic protein acts directly on the uterine endometrium and alters protein [9,13,25] and prostaglandin production [25,28].…”

Section: Introductionmentioning

confidence: 99%

Cellular localization of an embryonic interferon, ovine trophoblastin and its mRNA in sheep embryos during early pregnancy

Guillomot¹,

Michel²,

Gaye

et al. 1990

Biology of the Cell

100

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The ovine embryo produces an interferon named ovine Trophoblastin (oTP) which is involved in the maternal recognition of pregnancy and ensures the maintenance of progesterone secretion by the corpus luteum. We have used indirect immunohistofluorescence and in situ hybridization on histological sections to investigate the fate of this protein and its mRNA in ovine embryos from days 3 to 25 of pregnancy. The level of expression was measured by image analysis of the autoradiographs after in situ hybridization. Both techniques clearly demonstrated that oTP and its mRNA were specifically localized in the extra-embryonic trophoblast. Neither the embryonic cells, nor the yolk sac or the amniotic tissues produced the protein or its mRNA. The protein could be detected by d 11 of pregnancy in the elongated blastocyst. Maximum of expression is observed at d 14 and the level decreased by d 16 of pregnancy. The arrest of expression occurred in the regions of trophoblast which have established cellular contacts with the uterine epithelium during the implantation process.

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“…Expansion of the blastocoele and uterine and/or embryonic proteases results in the hatching of the blastocyst (approximately 300 cells) from the zona pellucida by Day 9 in sheep and Day 10 in cattle (Bindon 1969;Bindon 1971;Guillomot et al 1988;Hafez 1993;Chavatte-Palmer and Guillomot 2007). After hatching and prior to implantation, the ruminant blastocyst undergoes a rapid expansion that results in morphological changes and lengthening (Guillomot et al 1988). By Day 10, the blastocyst measures 400-900 µm in diameter and contains approximately 3000 cells .…”

Section: Conceptus Development and Implantation In Ruminantsmentioning

confidence: 99%

“…Endometrial functions are influenced by the hormonal status of the female (Guillomot et al 1988). Continuous exposure of the uterus to P4 induces expression of GE secretory products that are collectively termed histotroph (Brinsfield and Hawk 1974;Salamonsen et al 1985).…”

Section: Effects Of Progesteronementioning

confidence: 99%

Progesterone Regulation of Endometrial Gene Expression in the Early Pregnant Ovine Uterus.

Minten

Satterfield

Bazer

et al. 2010

Biology of Reproduction

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Establishment of pregnancy in ruminants requires blastocyst development to form an elongated filamentous conceptus that produces interferon tau (IFNT), the pregnancy recognition signal, and initiate implantation. Blastocyst growth and development is dependent upon secretions from the uterine endometrium. An early increase in post-ovulatory circulating levels of progesterone (P4) stimulates blastocyst growth and conceptus elongation in ruminants. Microarray analysis was used to identify candidate P4-regulated genes and regulatory networks in the endometrium that govern peri-implantation blastocyst/conceptus growth and development. The first study was conducted to validate effects of P4 and/or pregnancy on expression of candidate genes identified by microarray analysis. The genes included: ANGPTL3, CHGA,

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Embryo-uterine interactions during early stages of pregnancy in domestic mammals

Cited by 10 publications

References 44 publications

Microvasculature of regular and irregular areolae of the areola-gland subunit of the porcine placenta: structural and functional aspects

Microvasculature of regular and irregular areolae of the areola-gland subunit of the porcine placenta: structural and functional aspects

Cellular localization of an embryonic interferon, ovine trophoblastin and its mRNA in sheep embryos during early pregnancy

Progesterone Regulation of Endometrial Gene Expression in the Early Pregnant Ovine Uterus.

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