Embryonal prostatic rhabdomyosarcomas disguised presentation in an adolescent male: a case report

Abstract

Primary rhabdomyosarcoma of the prostate is a malignancy primarily of pediatric age group with most cases seen during infancy and childhood. Majority present with urinary symptoms but the case we report here presented at 16 years of age and had unusually nonspecific and temporally protracted nature of symptoms prior to the presentation. This remarkable unusualness lead to a delay in presentation and contributed to an eventually unfavorable outcome.

Primary Embryonal Rhabdomyosarcoma of the Prostate in Adults

“…Similar to Waring and Newland, 1 we also excluded from our review a total of 17 cases of rhabdomyosarcomas of the prostate affecting adults, which were not specifically categorized by the reporting authors, some of which could be ERMS 21-28 (Table 2). Moreover, we also excluded 3 cases of genuine prostatic ERMS occurring in 3 adolescents aged 15, 16, and 17 years 29-31 and 2 cases of mixed sarcomas (malignant phyllodes tumors with foci of ERMS), which were found in 2 patients aged 36 and 45 years, respectively. 32,33…”

Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient – case report and review of clinicopathological features

“…Most patients with prostatic ERMS die under therapy. Children and adolescents usually have a much better response to multimodal therapy than adults and primary surgical treatment is not standard of therapy [ 10 , 11 ]. In a retrospective study Wang et al analysed outcome of 25 adult patients with prostate sarcoma.…”

Primary Spindle Cell Rhabdomyosarcoma of Prostate: A Case Report with Review of Literature

“…Prostate sarcoma accounted For 3.21% of all the prostatic malignant tumors, the average age was 39.5 years old ranging from 17 to 62 years[3]. Patients with rhabdomyosarcoma showed rapidly progressive obstructive urinary symptoms, progressively worsening dyspnea on exertion and onset of skin nodules with polyarthralgias and low grade fever[4], smooth and fi rm enlargement of prostate on digital rectal examination, occasional suprapubic mass, regional lymph node spread, respiratory symptoms due to metastasis to lungs, osteoclastic bone metastases, and normal prostatic acid phosphates and prostate specifi c antigen levels[1,2].Spindle cell lesions of prostate displayed diagnostically challenging and encompass a broad array of benign and malignant neoplastic lesions. The differential diagnosis of spindle cell rhabdomyosarcoma are lesions arises only within the prostate and generally represents entities that originate from the prostate epithelium or stroma, such as sclerosing adenosis, sarcomatoid carcinoma, stromal tumors of uncertain malignant potential (STUMP), stromal sarcoma, solitary fi brous tumor, leiomyosarcoma, infl ammatory myofi broblastic tumour, gastrointestinal stromal tumour, fi brosarcoma and malignant peripheral nerve sheath tumour (Table 1).…”