Embryonal rhabdomyosarcoma of the uterine cervix: case report and review of the literature

Behtash, Nadereh; Mousavi, Azam Sadat; Tehranian, Afsaneh; Khanafshar, Navid; Hanjani, Parviz

doi:10.1016/s0090-8258(03)00539-0

Cited by 64 publications

(49 citation statements)

References 18 publications

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“…1 The head and neck were the most frequent sites of origin (35%), followed by the genitourinary tract (25%), extremities, trunk, retroperitoneum, and uncommon regions (intrathoracic, gastro-intestinal tract, perianal and anal regions). One of the least common sites for rhabdomyosarcoma in the genitourinary tract is the uterine cervix, but its occurrence has been well documented in the study of 13 cases.…”

Section: Introductionmentioning

confidence: 99%

“…Although ERMS has been described in females as young as 5 months of age, it tends to appear in an older age group (children or even young adults) than those occurring in the vagina. 1,3 The Intergroup Rhabdomyosarcoma Study Group (IRSG) has reported a new classification of ERMS distinguishing three major histological subtypes: embryonal, alveolar and undifferentiated. The embryonal subtype is the most common, accounting for 68% of all ERMS cases, with classic, botryoid and spindle cell variants embracing 49, 6 and 3%, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…The embryonal subtype is the most common, accounting for 68% of all ERMS cases, with classic, botryoid and spindle cell variants embracing 49, 6 and 3%, respectively. 1,3,4 Sarcoma botryoides of the cervix uteri rarely occurs in fertile age since it only accounts for 0.2% of all malignant tumours of the uterus. 4 This sarcoma generally presents as soft nodules that fill and sometimes protrude from the vagina, resembling a bunch of grapes.…”

Section: Introductionmentioning

confidence: 99%

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Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Gomes

Leite

Rocha

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Embryonal rhabdomyosarcoma of the female genital tract is a rare tumour. It tends to occur during childhood in the vagina and, rarely, it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of a 18-year-old female with an embryonal rhabdomyosarcoma (sarcoma botryoides) presenting himself as a cervical polyp. This tumour consisted of rhabdomyoblasts with miscellaneous differentiation surrounded by a loose, myxoid stroma. The patient was successfully treated with cervical conization and adjuvant chemotherapy. She is now disease-free at the 28th month follow-up. Awareness of this uncommon lesion in the cervix and its clinical implications is important to prevent misdiagnosis. Therapy has recently inclined to conservative and fertility-sparing treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Gomes

Leite

Rocha

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…These tumors arise from embryonal rhabdomyoblast and are approximately 3% of all rhabdomyosarcomas. The primary site of these tumors is closely related to the age of the patient; it is found in the vagina during infancy and early childhood, in the cervix during the reproductive age, and in the corpus uteri in post-menopausal patients (3,4).…”

Section: Introductionmentioning

confidence: 99%

Rhabdomyosarcoma of the Cervix, Local Excision or Radical Surgery (Report of Two Cases and Review of the Literature)

Akhavan¹,

Tehranian²,

Abadi³

2016

J Obstet Gynecol Cancer Res

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Introduction: Embryonal (Botryoid) Rhabdomyosarcoma (RMS) is an aggressive malignancy that arises from embryonal rhabdomyoblasts. It is commonly seen in the genital tract of female infants and young children. The primary site of these tumors is closely related to the age of the patient. Embryonal Rhabdomyosarcoma has a marked tendency for local recurrence after excision. Due to young age of affected patients who desire fertility, the management of this rapidly growing malignancy is very critical and poses challenges. Case Presentation: We report on two cases embryonal rhabdomyosarcoma of uterine cervix, who were referred to Imam Khomeini hospital during year 2014. Both of them were young virgin females. The presenting symptom for both was vaginal bleeding and protrusion of polypoid mass from the hymen. After neoadjuvant chemotherapy, radical hysterectomy was offered to them. One of them refused, thus local excision was done. Both patients received adjuvant chemotherapy yet in the patient with local excision, the tumor recurred with multiple metastases. Conclusions: There are several methods of surgical approach and variation in adjuvant therapy in the management of embryonal rhabdomyosarcoma. If we choose a conservative approach for surgery of early stage, surgical margin should be negative and in other cases doing radical surgery is the best.

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“…Since HPV is a DNA virus, its typing and characterization has been facilitated by DNA sequencing [8]. HPV virus, with inhibition apoptosis (planned cellular death) and with production of inhibitor proteins of P53 and retinoblastoma genes, leads to the accumulation of cancer cells into tumors [9][10][11][12]. More than 40 species of HPV virus, with ability to infect genital areas, have been recognized.…”

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confidence: 99%