2022
DOI: 10.1098/rstb.2021.0255
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Embryonic and extraembryonic tissues during mammalian development: shifting boundaries in time and space

Abstract: The first few days of embryonic development in eutherian mammals are dedicated to the specification and elaboration of the extraembryonic tissues. However, where the fetus ends and its adnexa begins is not always as self-evident during the early stages of development, when the definitive body axes are still being laid down, the germ layers being specified and a discrete form or bodyplan is yet to emerge. Function, anatomy, histomorphology and molecular identities have been used through the history of embryolog… Show more

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Cited by 17 publications
(12 citation statements)
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“…As expected, all blastocyst layers with sufficient representation had high auto-correlation in both replicates, indicating that a cell from a particular blastocyst layer is more likely to produce progeny that are also found in the same layer, reinforcing what is known about the rigidity of developmental programs [Thowfeequ and Srinivas, 2022]. Germ layers derived from outside of the epiblast had high auto-correlation in all replicates that had sufficient cell recovery, while tissues that shared a common origin in the epiblast had lower autocorrelations (Fig.…”
Section: Path Quantifies Ancestry and Divergence Of Germ Layers And C...supporting
confidence: 69%
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“…As expected, all blastocyst layers with sufficient representation had high auto-correlation in both replicates, indicating that a cell from a particular blastocyst layer is more likely to produce progeny that are also found in the same layer, reinforcing what is known about the rigidity of developmental programs [Thowfeequ and Srinivas, 2022]. Germ layers derived from outside of the epiblast had high auto-correlation in all replicates that had sufficient cell recovery, while tissues that shared a common origin in the epiblast had lower autocorrelations (Fig.…”
Section: Path Quantifies Ancestry and Divergence Of Germ Layers And C...supporting
confidence: 69%
“…S3B) . Thus, the non-epiblast-derived layers show evidence of earlier fate commitment, while the more plastic phenotype of the epiblast is consistent with its later divergence [Thowfeequ and Srinivas, 2022]. PATH also accurately reconstructed the patterns of shared ancestry between blastocyst layers and germ layers ( Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…For example, in the rodent, the early placenta (ectoplacental cone) is critical for the attachment of the embryo to the endometrium; however, during this early stage, the yolk sac is playing a vital role in nutrition. As both the placenta and yolk sac mature the visceral yolk sac everts itself and collects nutrients from the uterine environment and thus continues to assume a nutritional role as a transporter and metabolizer of proteins providing critical amino acids to the embryos development; (see Thowfeequ and Srinivas, 2022 for graphic descriptions of this embryonic development of the yolk sac). Interference with these yolk sac functions can compromise the development of the embryo (Brent et al, 1971; Freeman and Brown, 1980; 1983; 1986).…”
Section: Development and Structure Of The Visceral Yolk Sac In Rodentsmentioning
confidence: 99%
“…Matsuo et al [1] discuss developmental and mechanical roles of Reichert's membrane in mice, a non-cellular basal lamina separating trophectoderm and parietal yolk sac endoderm. Thowfeequ & Srinivas [2] present the idea of shifting boundaries between embryonic and extraembryonic tissues in time and space during early mouse development. Pfeffer [3] hypothesizes a connection between cavitation of the epiblast and loss of Rauber's layer (polar trophoblast covering the inner cell mass) in mammals.…”
Section: Introductionmentioning
confidence: 99%