Embryonic Brain Grafts in an Animal Model of Parkinson's Disease

Transplantation of Foetal Ventral Mesencephalic Grafts in Parkinson’s Disease: A Still Evolving Concept with New Regulatory Challenges

“…the putamen and caudate nucleus. While many investigators addressed this issue by performing studies on the administration of L-dopa in animal models or in patients in order to directly overcome the lack of this substance, others focussed on different strategies: Replacement of what is lost by transplanting dopamine producing cells into the diseased tissue or into regions depleted of dopamine, and thereby reversing the loss of function and initiating regeneration of function ( Björklund et al, 1982b;Freed, Cannon-Spoor & Wyatt, 1984b). Transplanting organs and tissues in clinical situations was becoming state of the art from the beginning of the last century on, but transplanting dopaminergic cells into the central nervous system (Figure 1) raised technical difficulties and was first performed in Sweden by…”

Towards New Therapies for Parkinson's Disease

“…Replacement of what is lost by transplanting dopamine producing cells into the diseased tissue or into regions depleted of dopamine, and thereby reversing the loss of function and initiating regeneration of function ( Björklund et al, 1982b;Freed, Cannon-Spoor & Wyatt, 1984b).…”

Article Commentary: A Perspective on Transplantation Therapy and Stem Cells for Parkinson's Disease

“…We actually proposed a set of What about experiments in monkeys? There have been only a few controlled studies in monkeys, mainly criteria for performing transplants in human subjects with Parkinson's disease many years ago (18,20). Al-by one group (62,63).…”