Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos

Gato, Á.; Moro, José; Alonso, Manuel García; Bueno, David; Mano, A. de la; Martín, Carlos M.

doi:10.1002/ar.a.20185

Cited by 94 publications

(147 citation statements)

References 56 publications

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“…Many such signals have been found in fetal CSF (fCSF), indicating that fCSF is part of the neurogenic niche (Owen-Lynch et al, 2003;Gato et al, 2005;Miyan et al, 2006;Johanson et al, 2008Johanson et al, , 2011Gato and Desmond, 2009). Two proteomic analyses of fetal CSF of rats and humans have revealed numerous compounds that likely are cues for diff erent phases of neurogenesis (Parada et al, 2005;Zappaterra et al, 2007).…”

Section: Alterations Of the Microenvironment Of The Neu-rogenic Nichementioning

confidence: 99%

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus

et al. 2012

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Most cells of the developing mammalian brain derive from the ventricular (VZ) and the subventricular (SVZ) zones. The VZ is formed by the multipotent radial glia/neural stem cells (NSCs) while the SVZ harbors the rapidly proliferative neural precursor cells (NPCs). Evidence from human and animal models indicates that the common history of hydrocephalus and brain maldevelopment starts early in embryonic life with disruption of the VZ and SVZ. We propose that a "cell junction pathology" involving adherent and gap junctions is a fi nal common outcome of a wide range of gene mutations resulting in proteins abnormally expressed by the VZ cells undergoing disruption. Disruption of the VZ during fetal development implies the loss of NSCs whereas VZ disruption during the perinatal period implies the loss of ependyma. The process of disruption occurs in specifi c regions of the ventricular system and at specifi c stages of brain development. This explains why only certain brain structures have an abnormal development, which in turn results in a specifi c neurological impairment of the newborn. Disruption of the VZ of the Sylvian aqueduct (SA) leads to aqueductal stenosis and hydrocephalus, while disruption of the VZ of telencephalon impairs neurogenesis. We are currently investigating whether grafting of NSCs/neurospheres from normal rats into the CSF of hydrocephalic mutants helps to diminish/repair the outcomes of VZ disruption.

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Section: Alterations Of the Microenvironment Of The Neu-rogenic Nichementioning

confidence: 99%

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus

et al. 2012

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“…Moreover, lineage tracing showed colonies cocultured with endothelial cells continued to undergo expansive symmetric divisions and lacked asymmetric neuron-generating divisions seen in neural stem cell colonies alone (Shen et al, 2004). CSF has been shown to maintain the survival, proliferation, and differentiation of neuroepithelial cells in vitro (Gato et al, 2005;Miyan et al, 2006). Furthermore, a recent in vivo study that drained the CSF and administered BrdU found a marked decrease in proliferation 3 days after analysis and suggests a role of the CSF in regulating neural stem/precursor cell proliferation (Mashayekhi and Salehi, 2006).…”

Section: Similarities and Differences Between Adult And Fetal Neural mentioning

confidence: 99%

The microenvironment of the embryonic neural stem cell: Lessons from adult niches?

Lathia

Rao

Mattson

et al. 2007

Developmental Dynamics

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A better understanding of the signals regulating embryonic neural stem cells is clearly an important goal. However, many studies on neural stem cell biology are conducted on the slowly-dividing cells found in the adult CNS, where specialized microenvironments or niches maintain the stem cells throughout life. By contrast, the embryonic VZ is a transient structure that does not fulfill the criteria conventionally used to define niches. In this review we will examine whether, despite these differences, the signals found in other adult stem cell niches are present in the VZ. Using the similarities and differences we observe, we will reconsider whether the location of embryonic stem cell populations such as the VZ can be thought of as niches. Finally, we will ask how these lessons from the niche inform our understanding of neurodevelopmental diseases and cancers of the CNS. Developmental Dynamics 236:3267-3282, 2007.

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“…Growing evidence suggests that CSF plays an important role not only in brain development but also in survival and proliferation of neuroectodermal stem cell (13). A previous study showed that adult CSF facilitates gliogenesis from the fetal rat neural stem cell (5).…”

Section: Immediately After Electrophysiological Evaluation Middlementioning

confidence: 99%

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

Farjah

Dolatkhah²,

Pourheidar³

et al. 2015

Turkish Neurosurgery

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ABSTRACTgaps by inserting the severed nerve stumps into the two ends of the canal (16). Some natural and synthetic substances can be shaped in structures that are able to promote nerve regeneration for example: eggshell membrane (12), silicone (31), human amnion layer (22), collagen (18), collagen-Chitosan (36).Collagen-based biomaterials have been extensively studied as a promising nerve guide (7). Since collagen is a natural material, it shows excellent biocompatibility, insignificant immunogenicity, and high bio-absorbability (27).█ INTRODUCTION F or peripheral nerve repair, nerve autografts have always been considered as the "gold standard" for the restoration of structural and functional nerve regeneration (34).Autograft has several disadvantages, including the need for an extra-incision, loss of donor nerve function, mismatch in size between the donor nerve and the injured nerve, and a limited availability of donor nerve (33). To solve these problems, nerve guide channels (NGCs) have been made to bridge the nerve AIm: The aim of this study was to evaluate the effect of cerebrospinal fluid (CSF) in nerve regeneration across the collagen guide channel in comparison with autograft. mATERIAl and mEThODS: Forty adult male rats (250-300 g) were randomized into (1) collagen channel+CSF, (2) collagen channel+normal saline (NS), (3) autograft, and (4) sham surgery groups. The left sciatic nerve was exposed and a 10 mm nerve segment was cut and removed. In the collagen groups, the proximal and distal cuts ends of sciatic nerve were telescoped into the nerve guides and CSF or NS injected into collagen conduit. In the autograft group, the 10 mm nerve segment was turned backwards and used an autologous nerve graft. All animals were evaluated by sciatic functional index (SFI) and electrophysiology, histology, and immunohistochemistry testing. RESUlTS:The improvements in SFI since the beginning of the last evaluation in experimental groups were measured. On days 49 and 60 post-operation, the mean SFI of the collagen+CSF group was significantly greater than the autograft group (P< 0.05). On day 90, the mean nerve conduction velocity (NCV) of the collagen+CSF group was greater than autograft group (P< 0.05). The number of myelinated fibers in the collagen+CSF group was significantly greater than that of the collagen + NS group at day 90 (P<0.05).CONClUSION: CSF in collagen nerve guide channel effectively enhances nerve regeneration and promotes functional recovery in injured sciatic nerve of rats.

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Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos

Cited by 94 publications

References 56 publications

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus

The microenvironment of the embryonic neural stem cell: Lessons from adult niches?

The effect of cerebro-spinal fluid in collagen guide channel on sciatic nerve regeneration in rat

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