Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice

Slima, Ahlem Ben; Abdallah, Ferjani Ben; Keskes, Leila; Mallek, Z.; Feki, Abdelfattah El; Gdoura, Radhouane

doi:10.1111/j.1439-0272.2011.01246.x

Cited by 15 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decline in testicular weight might be due to the decline in serum testosterone levels (as obtained in our unpublished work). Our findings on reduced testicular weight also corroborates to that of earlier workers who observed a similar reduction in the weight of testis, epididymis, seminal vesicle and prostrate in Deltamethrin (EC) exposed Sprague Dawley rats for a period of 35 days 33,34,35 .…”

Section: Glycogensupporting

confidence: 92%

Untitled

2015

IJPSR

View full text Add to dashboard Cite

Present study was carried out to assess testicular toxicity of pyrethroid insecticide, Deltamethrin (DM) in male Swiss albino mice, Mus musculus and to evaluate protective role of Allium sativum (AS) in alleviating the detrimental effect of DM. Forty male mice were divided into five experimental groups (8 mice per group) and were categorized : Control-Given distilled water and food ad libitum, Vehicle Control (oil)-Given peanut oil, DM treated-Given 1/5 th of LD 50 (6 mg/kg body weight) of DM dissolved in peanut oil via oral gavage, AS-given Allium sativum only (200 mg/kg body weight), DM + AS-given Deltamethrin along with Allium sativum (6 mg/kg body wt. + 200 mg/kg body wt.). Experiment was conducted for a duration of 45 days. DM caused a significant reduction in body weight, testicular weight, Total Protein, Superoxide Dismutase (SOD), Catalase (CAT), Glutathione (GSH), Glutathione Peroxidase (GPx), Glutathione Reductase (GRx), Glutathione-S-Transferase (GST) and Glycogen content of testis. DMtreated group also showed a significant increase in testicular malondialdehyde (MDA) and Cholesterol concentrations. Conversely, treatment with Allium sativum improved the DM-induced oxidative damage and other evaluated indices of testes. Results indicate that DM exerts significant harmful effects on male mice and concurrent administration of Allium sativum ameliorates the detrimental effects of DM. INTRODUCTION: Under the pretext of demographic growth with all its consequences, agricultural production resorts to the use of a varied and a large quantity of insecticides to improve the production and preservation of food stuffs. Thus, the use of insecticides has increased rapidly and is now widespread to the lowest level of agricultural production. Synthetic pyrethroids are modified derivatives of pyrethins, natural substances obtained from flowers of pyrethrum species.

show abstract

Section: Glycogensupporting

confidence: 92%

Untitled

2015

IJPSR

View full text Add to dashboard Cite

show abstract

“…Pyrethroid‐induced male reproductive toxicity continues to be an active area of research because of the fact that the majority of the human population is exposed to these chemicals on a routine basis, that is, intake of the residual pyrethroids present in the food, use of insect repellents for household pest management and spraying on crops. Research reports in the last 5 years indicate that exposure to pyrethroids resulted in delayed Leydig cell development, [ 24 ] endocrine disruption, reproductive dysfunction, [ 25‐27 ] , and alterations in the epithelial and stromal cells of the prostate. [ 28 ] We demonstrated that exposure to allethrin caused reproductive dysfunction in male rats and disruption of expression of genes involved in germ cell production.…”

Section: Introductionmentioning

confidence: 99%

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Ravula

Yenugu

2020

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Humans are exposed to pyrethroid‐based pesticides through agricultural produce. In this study, male Wistar rats were orally treated for 9 to 12 months with a mixture of pyrethroids that is equivalent to one‐fifth (high dose; HD) or one‐twenty fifth (low dose; LD) of the amount of pyrethroids present in the cereals and rice consumed by an average Indian. In rats treated for 9 months, the spermatogenesis‐associated genes Abp, Ar, Cd9, Dax1, Dazap1, Ddx3y, Gdnf, Gfra1, Grth, Inhb, Ovol1, P1, Plzf, Pygo2, Scf, Tgfb1, Tp1, Tp2, and Vim1 were downregulated in both LD and HD groups. In rats treated for 12 months Gdnf, Hsf2, Inhb, Tgfb1, Thy1, and Ybx2 expression was downregulated in both LD and HD groups. Steroidogenesis‐associated genes 17‐β‐Hsd, Gata4, Hmgcr, Hmgcs1, Pde4b, and Tspo gene expression were reduced in both LD‐ and HD‐treated groups treated for 9 months. In 12‐month‐treated rats, Creb1 expression decreased in both LD and HD groups. The epigenetic reprogramming‐associated genes, Dnmt1, Dnmt3a, Dnmt3b, Hdac10, Hp1bp3, Kat3a Kat3b, Mch2ta, Ncoa7, and Sirt1 were downregulated in both HD and LD groups of 9‐months‐treated rats. In rats treated for 12 months, Hdac10, Mch2ta, Ncoa7, and Sirt1 messenger RNA levels decreased in both the HD and LD groups. Thus, we demonstrate that long‐term exposure to a mixture of pyrethroids caused aberrations in the transcriptome of factors involved in sperm production and development.

show abstract

“…11 Delta has been shown to have adverse effects on male and female reproductive system. 12 In recent years, endocrine disruptors may be found in many products-including pesticides. These chemical products can block the signaling systems of hormones.…”

Section: Introductionmentioning

confidence: 99%

Endocrine disrupting potential and reproductive dysfunction in male mice exposed to deltamethrin

et al. 2016

View full text Add to dashboard Cite

Pesticide exposure may affect semen quality and male fertility in humans. The aim of the present work was to elucidate the adverse effects of deltamethrin (Delta), a synthetic pyrethroid, on exposed male mice and their offspring. Adult male Albino/Swiss mice received deltamethrin (5 mg/kg) daily for 35 days and mated with untreated females to produce offspring. Classical measurements of ejaculate and sperm quality and testicular histopathological changes were assessed. Deltamethrin treatment affects sperm quality and quantity in the ejaculated semen of mice that had also markedly impaired libido as measured by indices of mating and fertility and number of pregnant females housed with male mice exposed to this pesticide. Exposure mice to deltamethrin significantly decreased their testosterone and inhibin B levels and affected reproductive performance. Testes of exposed mice showed marked histopathological alterations as compared to the control group. The mice exposed to 5 mg/kg body weight/day of deltamethrin showed severe alterations of the seminiferous tubules, sloughing of the germ cells, the vacuolization of germ cell cytoplasm, and the disruption of spermatogenic cells compared to the control group. Altered pregnancy outcomes were directly attributed to damage of sperm of male mice exposed to deltamethrin compared to the control group. We concluded that exposure to deltamethrin affected the reproductive system of male mice explored by altered total sperm density, motility, and morphology in mice spermatozoa.

show abstract

Embryonic exposure to dimethoate and/or deltamethrin impairs sexual development and programs reproductive success in adult male offspring mice

Cited by 15 publications

References 15 publications

Untitled

Untitled

Effect of long‐term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats

Endocrine disrupting potential and reproductive dysfunction in male mice exposed to deltamethrin

Contact Info

Product

Resources

About